Chiral recognition based on calix[4]arene

Chiral calixarenes are a class of important host compounds and have wide applications in chiral recognition, enantiomer separation and asymmetrical catalysis. Calix [4] arene is investigated most widely due to its stable conformation and easy derivatization. Among them lots of works reported the chiral calix [ 4 ] arenes can be used in enantiomeric recognition and dectection. Fluorescence, UV-vis and NMR are the most common methods in the research of chiral recognition. According to these methods, the latest research progress in the synthesis of chiral receptors based on calix [4] arenes and their applications in the chiral recognition are summarized. The prospect of chiral calix[4] arene is also discussed.