Chiral phosphoric acid-catalyzed transfer hydrogenation of 3,3-difluoro-3H-indoles

Yumei Wang; Guangzhu Wang; Yanping Zhu; Kaiwu Dong

doi:10.3762/bjoc.20.20

Chiral phosphoric acid-catalyzed transfer hydrogenation of 3,3-difluoro-3H-indoles

Yumei Wang
, Guangzhu Wang
, Yanping Zhu^*
, Kaiwu Dong^*

^*此作品的通讯作者

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

A convenient and efficient method for the synthesis of optically active difluoro-substituted indoline derivatives starting from the corresponding 3H-indoles by chiral phosphoric acid-catalyzed transfer hydrogenation was developed. Using Hantzsch ester as the hydrogen source under mild reaction conditions, the target products can be obtained with excellent yield and enantioselectivity.

源语言	英语
页（从-至）	205-211
页数	7
期刊	Beilstein Journal of Organic Chemistry
卷	20
DOI	https://doi.org/10.3762/bjoc.20.20
出版状态	已出版 - 2024

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title = "Chiral phosphoric acid-catalyzed transfer hydrogenation of 3,3-difluoro-3H-indoles",

abstract = "A convenient and efficient method for the synthesis of optically active difluoro-substituted indoline derivatives starting from the corresponding 3H-indoles by chiral phosphoric acid-catalyzed transfer hydrogenation was developed. Using Hantzsch ester as the hydrogen source under mild reaction conditions, the target products can be obtained with excellent yield and enantioselectivity.",

keywords = "3,3-difluoroindoline, Hantzsch ester, asymmetric organocatalysis, chiral Br{\o}nsted acid, transfer hydrogenation",

author = "Yumei Wang and Guangzhu Wang and Yanping Zhu and Kaiwu Dong",

note = "Publisher Copyright: {\textcopyright} 2024 Wang et al.",

year = "2024",

doi = "10.3762/bjoc.20.20",

language = "英语",

volume = "20",

pages = "205--211",

journal = "Beilstein Journal of Organic Chemistry",

issn = "2195-951X",

publisher = "Beilstein-Institut Zur Forderung der Chemischen Wissenschaften",

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TY - JOUR

T1 - Chiral phosphoric acid-catalyzed transfer hydrogenation of 3,3-difluoro-3H-indoles

AU - Wang, Yumei

AU - Wang, Guangzhu

AU - Zhu, Yanping

AU - Dong, Kaiwu

PY - 2024

Y1 - 2024

N2 - A convenient and efficient method for the synthesis of optically active difluoro-substituted indoline derivatives starting from the corresponding 3H-indoles by chiral phosphoric acid-catalyzed transfer hydrogenation was developed. Using Hantzsch ester as the hydrogen source under mild reaction conditions, the target products can be obtained with excellent yield and enantioselectivity.

AB - A convenient and efficient method for the synthesis of optically active difluoro-substituted indoline derivatives starting from the corresponding 3H-indoles by chiral phosphoric acid-catalyzed transfer hydrogenation was developed. Using Hantzsch ester as the hydrogen source under mild reaction conditions, the target products can be obtained with excellent yield and enantioselectivity.

KW - 3,3-difluoroindoline

KW - Hantzsch ester

KW - asymmetric organocatalysis

KW - chiral Brønsted acid

KW - transfer hydrogenation

UR - https://www.scopus.com/pages/publications/85186092554

U2 - 10.3762/bjoc.20.20

DO - 10.3762/bjoc.20.20

M3 - 文章

AN - SCOPUS:85186092554

SN - 2195-951X

VL - 20

SP - 205

EP - 211

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

ER -

Chiral phosphoric acid-catalyzed transfer hydrogenation of 3,3-difluoro-3H-indoles

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