Chemo-Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with α-Diazo Ketones Tuned by Reaction Conditions

Xinrong Zhi; Xinyu Huang; Xin Ji; Lu Liu

doi:10.1002/cmtd.202500108

Chemo-Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with α-Diazo Ketones Tuned by Reaction Conditions

Xinrong Zhi
, Xinyu Huang
, Xin Ji
, Lu Liu^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

A chemo-divergent Friedel–Crafts alkylation and Friedel–Crafts acylation of arenes with α-diazo ketones has been developed. In this reaction, Cu(OTf)₂ catalyzed the Friedel–Crafts alkylation via Cu-carbene intermediate, while hexafluoroisopropanol (HFIP) promoted the Friedel–Crafts acylation via the ketene intermediate. This protocol provides a controllable aromatic C(sp2).H bond functionalization of arenes by tuning the reaction conditions.

源语言	英语
文章编号	e202500108
期刊	Chemistry-Methods
卷	6
期	1
DOI	https://doi.org/10.1002/cmtd.202500108
出版状态	已出版 - 1月 2026

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title = "Chemo-Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with α-Diazo Ketones Tuned by Reaction Conditions",

abstract = "A chemo-divergent Friedel–Crafts alkylation and Friedel–Crafts acylation of arenes with α-diazo ketones has been developed. In this reaction, Cu(OTf)2 catalyzed the Friedel–Crafts alkylation via Cu-carbene intermediate, while hexafluoroisopropanol (HFIP) promoted the Friedel–Crafts acylation via the ketene intermediate. This protocol provides a controllable aromatic C(sp2).H bond functionalization of arenes by tuning the reaction conditions.",

keywords = "C.H bond functionalization, Friedel-Crafts alkylation, Friedel–Crafts acylation, diazo ketones, ketene",

author = "Xinrong Zhi and Xinyu Huang and Xin Ji and Lu Liu",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Chemistry - Methods published by Chemistry Europe and Wiley-VCH GmbH.",

year = "2026",

month = jan,

doi = "10.1002/cmtd.202500108",

language = "英语",

volume = "6",

journal = "Chemistry-Methods",

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publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - Chemo-Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with α-Diazo Ketones Tuned by Reaction Conditions

AU - Zhi, Xinrong

AU - Huang, Xinyu

AU - Ji, Xin

AU - Liu, Lu

PY - 2026/1

Y1 - 2026/1

N2 - A chemo-divergent Friedel–Crafts alkylation and Friedel–Crafts acylation of arenes with α-diazo ketones has been developed. In this reaction, Cu(OTf)2 catalyzed the Friedel–Crafts alkylation via Cu-carbene intermediate, while hexafluoroisopropanol (HFIP) promoted the Friedel–Crafts acylation via the ketene intermediate. This protocol provides a controllable aromatic C(sp2).H bond functionalization of arenes by tuning the reaction conditions.

AB - A chemo-divergent Friedel–Crafts alkylation and Friedel–Crafts acylation of arenes with α-diazo ketones has been developed. In this reaction, Cu(OTf)2 catalyzed the Friedel–Crafts alkylation via Cu-carbene intermediate, while hexafluoroisopropanol (HFIP) promoted the Friedel–Crafts acylation via the ketene intermediate. This protocol provides a controllable aromatic C(sp2).H bond functionalization of arenes by tuning the reaction conditions.

KW - C.H bond functionalization

KW - Friedel-Crafts alkylation

KW - Friedel–Crafts acylation

KW - diazo ketones

KW - ketene

UR - https://www.scopus.com/pages/publications/105020706449

U2 - 10.1002/cmtd.202500108

DO - 10.1002/cmtd.202500108

M3 - 文章

AN - SCOPUS:105020706449

SN - 2628-9725

VL - 6

JO - Chemistry-Methods

JF - Chemistry-Methods

IS - 1

M1 - e202500108

ER -

Chemo-Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with α-Diazo Ketones Tuned by Reaction Conditions

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