Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

Mingshu Xiao; Li Li; Hao Pei

doi:10.1007/978-1-0716-4394-5_9

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

Mingshu Xiao
, Li Li
, Hao Pei^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 书/报告/会议事项章节 › 章节 › 同行评审

摘要

Developing simple, yet effective strategies to program cell–cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.

源语言	英语
主期刊名	Methods in Molecular Biology
出版商	Humana Press Inc.
页	117-130
页数	14
DOI	https://doi.org/10.1007/978-1-0716-4394-5_9
出版状态	已出版 - 2025

丛书

姓名	Methods in Molecular Biology
卷	2901
ISSN（印刷版）	1064-3745
ISSN（电子版）	1940-6029

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1007/978-1-0716-4394-5_9

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abstract = "Developing simple, yet effective strategies to program cell{\textendash}cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.",

keywords = "Cell surface engineering, Cell-based immunotherapy, Cell{\textendash}cell interactions, DNA circuit, Framework nucleic acid",

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AU - Xiao, Mingshu

AU - Li, Li

AU - Pei, Hao

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025

Y1 - 2025

N2 - Developing simple, yet effective strategies to program cell–cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.

AB - Developing simple, yet effective strategies to program cell–cell interactions facilitate the study of fundamental multicellular behavior and the development of cell-based therapeutics. Here we report cell-membrane-anchored DNA nanoplatform for programming cellular interactions. The membrane-anchored framework nucleic acid clustering can be programmed by DNA probabilistic circuits, to modulate the recognition capability of natural killer cells and control their interactions with cancer cells for enhancing efficient cancer cell killing. This work provides insights for precise control over cellular interactions and opens new opportunities for the development of cell-based immunotherapy.

KW - Cell surface engineering

KW - Cell-based immunotherapy

KW - Cell–cell interactions

KW - DNA circuit

KW - Framework nucleic acid

UR - https://www.scopus.com/pages/publications/105002823656

U2 - 10.1007/978-1-0716-4394-5_9

DO - 10.1007/978-1-0716-4394-5_9

M3 - 章节

C2 - 40175871

AN - SCOPUS:105002823656

T3 - Methods in Molecular Biology

SP - 117

EP - 130

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

摘要

丛书

联合国可持续发展目标

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