Catalytic asymmetric acylcyanation of imines

Subhas Chandra Pan; Jian Zhou; Benjamin List

doi:10.1002/anie.200603630

Catalytic asymmetric acylcyanation of imines

Subhas Chandra Pan^*
, Jian Zhou
, Benjamin List

^*此作品的通讯作者

Max Planck Institute for Coal Research

科研成果: 期刊稿件 › 文章 › 同行评审

141 引用（Scopus）

摘要

(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.

源语言	英语
页（从-至）	612-614
页数	3
期刊	Angewandte Chemie - International Edition
卷	46
期	4
DOI	https://doi.org/10.1002/anie.200603630
出版状态	已出版 - 2007
已对外发布	是

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title = "Catalytic asymmetric acylcyanation of imines",

abstract = "(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.",

keywords = "Acylcyanation, Asymmetric catalysis, Organocatalysis, Strecker reaction, Thiourea",

author = "Pan, \{Subhas Chandra\} and Jian Zhou and Benjamin List",

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T1 - Catalytic asymmetric acylcyanation of imines

AU - Pan, Subhas Chandra

AU - Zhou, Jian

AU - List, Benjamin

PY - 2007

Y1 - 2007

N2 - (Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.

AB - (Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desired α-amidonitrile is obtained in excellent enantioselectivity and yield.

KW - Acylcyanation

KW - Asymmetric catalysis

KW - Organocatalysis

KW - Strecker reaction

KW - Thiourea

UR - https://www.scopus.com/pages/publications/33846542040

U2 - 10.1002/anie.200603630

DO - 10.1002/anie.200603630

M3 - 文章

C2 - 17154433

AN - SCOPUS:33846542040

SN - 1433-7851

VL - 46

SP - 612

EP - 614

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 4

ER -

Catalytic asymmetric acylcyanation of imines

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