Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

Liang Jun Xie; Lili Chen; Senmiao Xu

doi:10.1055/a-2335-8677

Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

Liang Jun Xie
, Lili Chen^*
, Senmiao Xu^*

^*此作品的通讯作者

CAS - Lanzhou Institute of Chemical Physics
University of Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

Reported here is the iridium-catalyzed regio- and enantio selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[ d ]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one boryl ated product could undergo stereospecific transformations to form a series of C-C and C-heteroatom bonds.

源语言	英语
页（从-至）	2638-2647
页数	10
期刊	Synthesis (Germany)
卷	56
期	17
DOI	https://doi.org/10.1055/a-2335-8677
出版状态	已出版 - 14 8月 2024
已对外发布	是

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title = "Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis",

abstract = "Reported here is the iridium-catalyzed regio- and enantio selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[ d ]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one boryl ated product could undergo stereospecific transformations to form a series of C-C and C-heteroatom bonds.",

keywords = "C-H activation, asymmetric catalysis, borylation, chiral bidentate boryl ligands, synthetic methods",

author = "Xie, \{Liang Jun\} and Lili Chen and Senmiao Xu",

year = "2024",

month = aug,

day = "14",

doi = "10.1055/a-2335-8677",

language = "英语",

volume = "56",

pages = "2638--2647",

journal = "Synthesis (Germany)",

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TY - JOUR

T1 - Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

AU - Xie, Liang Jun

AU - Chen, Lili

AU - Xu, Senmiao

PY - 2024/8/14

Y1 - 2024/8/14

N2 - Reported here is the iridium-catalyzed regio- and enantio selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[ d ]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one boryl ated product could undergo stereospecific transformations to form a series of C-C and C-heteroatom bonds.

AB - Reported here is the iridium-catalyzed regio- and enantio selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[ d ]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one boryl ated product could undergo stereospecific transformations to form a series of C-C and C-heteroatom bonds.

KW - C-H activation

KW - asymmetric catalysis

KW - borylation

KW - chiral bidentate boryl ligands

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/85195424056

U2 - 10.1055/a-2335-8677

DO - 10.1055/a-2335-8677

M3 - 文章

AN - SCOPUS:85195424056

SN - 0039-7881

VL - 56

SP - 2638

EP - 2647

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 17

ER -

Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

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