Azobenzene-bridged bile acid dimers: An interesting class of conjugates with conformation-controlled bioactivity

Weina Li; Yan Li; Xianpeng Yin; Yun Liang; Jian Li; Chen Wang; Yue Lan; Hui Wang; Yong Ju; Guangtao Li

doi:10.1016/j.tetlet.2016.04.107

Azobenzene-bridged bile acid dimers: An interesting class of conjugates with conformation-controlled bioactivity

Weina Li
, Yan Li
, Xianpeng Yin
, Yun Liang
, Jian Li
, Chen Wang
, Yue Lan
, Hui Wang
, Yong Ju
, Guangtao Li^*

^*此作品的通讯作者

Qingdao Agricultural University
Tsinghua University

科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

The synergetic combination of the distinct properties of azobenzene and bile acid could afford stable tweezer-like conformation with tunable hydrophilic and hydrophobic channels, thus increasing their antimicrobial activity toward both Gram-positive and Gram-negative bacteria, which can be conveniently switched off when the conformation turn back to the extended state.

源语言	英语
页（从-至）	2539-2543
页数	5
期刊	Tetrahedron Letters
卷	57
期	23
DOI	https://doi.org/10.1016/j.tetlet.2016.04.107
出版状态	已出版 - 8 6月 2016
已对外发布	是

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10.1016/j.tetlet.2016.04.107

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title = "Azobenzene-bridged bile acid dimers: An interesting class of conjugates with conformation-controlled bioactivity",

abstract = "The synergetic combination of the distinct properties of azobenzene and bile acid could afford stable tweezer-like conformation with tunable hydrophilic and hydrophobic channels, thus increasing their antimicrobial activity toward both Gram-positive and Gram-negative bacteria, which can be conveniently switched off when the conformation turn back to the extended state.",

keywords = "Antibacterial activity, Azobenzene, Bile acid, Conformation, Dimers",

author = "Weina Li and Yan Li and Xianpeng Yin and Yun Liang and Jian Li and Chen Wang and Yue Lan and Hui Wang and Yong Ju and Guangtao Li",

year = "2016",

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doi = "10.1016/j.tetlet.2016.04.107",

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T1 - Azobenzene-bridged bile acid dimers

T2 - An interesting class of conjugates with conformation-controlled bioactivity

AU - Li, Weina

AU - Li, Yan

AU - Yin, Xianpeng

AU - Liang, Yun

AU - Li, Jian

AU - Wang, Chen

AU - Lan, Yue

AU - Wang, Hui

AU - Ju, Yong

AU - Li, Guangtao

PY - 2016/6/8

Y1 - 2016/6/8

N2 - The synergetic combination of the distinct properties of azobenzene and bile acid could afford stable tweezer-like conformation with tunable hydrophilic and hydrophobic channels, thus increasing their antimicrobial activity toward both Gram-positive and Gram-negative bacteria, which can be conveniently switched off when the conformation turn back to the extended state.

AB - The synergetic combination of the distinct properties of azobenzene and bile acid could afford stable tweezer-like conformation with tunable hydrophilic and hydrophobic channels, thus increasing their antimicrobial activity toward both Gram-positive and Gram-negative bacteria, which can be conveniently switched off when the conformation turn back to the extended state.

KW - Antibacterial activity

KW - Azobenzene

KW - Bile acid

KW - Conformation

KW - Dimers

UR - https://www.scopus.com/pages/publications/84968854659

U2 - 10.1016/j.tetlet.2016.04.107

DO - 10.1016/j.tetlet.2016.04.107

M3 - 文章

AN - SCOPUS:84968854659

SN - 0040-4039

VL - 57

SP - 2539

EP - 2543

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 23

ER -

Azobenzene-bridged bile acid dimers: An interesting class of conjugates with conformation-controlled bioactivity

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