Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo

Min Li; Chuanfeng Wang; Ting Wang; Mengting Fan; Ning Wang; Danying Ma; Ting Hu; Xiaoyan Cui

doi:10.1039/c9cc09666c

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo

Min Li
, Chuanfeng Wang
, Ting Wang
, Mengting Fan
, Ning Wang
, Danying Ma
, Ting Hu
, Xiaoyan Cui

化学与分子工程学院

East China Normal University
Naval Medical University

科研成果: 期刊稿件 › 文章 › 同行评审

19 引用（Scopus）

摘要

A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

源语言	英语
页（从-至）	2455-2458
页数	4
期刊	Chemical Communications
卷	56
期	16
DOI	https://doi.org/10.1039/c9cc09666c
出版状态	已出版 - 25 2月 2020

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10.1039/c9cc09666c

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abstract = "A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.",

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AU - Li, Min

AU - Wang, Chuanfeng

AU - Wang, Ting

AU - Fan, Mengting

AU - Wang, Ning

AU - Ma, Danying

AU - Hu, Ting

AU - Cui, Xiaoyan

PY - 2020/2/25

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AB - A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

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Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes: In vivo

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