TY - JOUR
T1 - Association between XRCC1 Arg280his polymorphism and risk of hepatocellular carcinoma
T2 - A systematic review and meta-analysis
AU - Xu, W.
AU - Liu, S. A.
AU - Li, L.
AU - Shen, Z. Y.
AU - Wu, Y. L.
N1 - Publisher Copyright:
© FUNPEC-RP.
PY - 2015
Y1 - 2015
N2 - Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision repair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, particularly the Arg280His polymorphism. However, the data is inconsistent and incomplete. In this study, we conducted a meta-analysis to investigate the association between the XRCC1 Arg280His polymorphism and HCC risk. A total of 10 case-control studies included 1848 HCC cases and 1969 controls were examined in this analysis. Our results suggest that variant genotypes of the XRCC1 Arg280His gene are associated with a significantly increased risk of HCC in homozygote comparison (HisHis vs ArgArg, odds ratio, 1.55, 95% confidence interval, 1.10-2.18, P = 0.013); no heterogeneity was observed (I2 = 0%). Our analysis suggests that the XRCC1 Arg280His polymorphism is associated with a higher risk of HCC.
AB - Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision repair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, particularly the Arg280His polymorphism. However, the data is inconsistent and incomplete. In this study, we conducted a meta-analysis to investigate the association between the XRCC1 Arg280His polymorphism and HCC risk. A total of 10 case-control studies included 1848 HCC cases and 1969 controls were examined in this analysis. Our results suggest that variant genotypes of the XRCC1 Arg280His gene are associated with a significantly increased risk of HCC in homozygote comparison (HisHis vs ArgArg, odds ratio, 1.55, 95% confidence interval, 1.10-2.18, P = 0.013); no heterogeneity was observed (I2 = 0%). Our analysis suggests that the XRCC1 Arg280His polymorphism is associated with a higher risk of HCC.
KW - Hepatocellular carcinoma
KW - Meta-analysis
KW - Single nucleotide polymorphism
KW - XRCC1-Arg280His
UR - https://www.scopus.com/pages/publications/84936090243
U2 - 10.4238/2015.June.29.5
DO - 10.4238/2015.June.29.5
M3 - 文章
C2 - 26125922
AN - SCOPUS:84936090243
SN - 1676-5680
VL - 14
SP - 7122
EP - 7129
JO - Genetics and Molecular Research
JF - Genetics and Molecular Research
IS - 2
M1 - A435
ER -