Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

Mengyang Zhang; Junqing He; Youbin Zheng; Guoyue Shi; Min Zhang

doi:10.1039/d2an01393b

Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

Mengyang Zhang
, Junqing He
, Youbin Zheng
, Guoyue Shi
, Min Zhang^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Technion-Israel Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

源语言	英语
页（从-至）	4413-4416
页数	4
期刊	Analyst
卷	147
期	20
DOI	https://doi.org/10.1039/d2an01393b
出版状态	已出版 - 21 10月 2022

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10.1039/d2an01393b

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abstract = "Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.",

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AU - Zhang, Mengyang

AU - He, Junqing

AU - Zheng, Youbin

AU - Shi, Guoyue

AU - Zhang, Min

PY - 2022/10/21

Y1 - 2022/10/21

N2 - Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

AB - Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

UR - https://www.scopus.com/pages/publications/85139572123

U2 - 10.1039/d2an01393b

DO - 10.1039/d2an01393b

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Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring

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