Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

Kuo Kan Liang; Michitoshi Hayashi; Ying Jen Shiu; Yan Mo; Jiushu Shao; Yijing Yan; Sheng Hsien Lin

doi:10.1002/jccs.200300050

Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

Kuo Kan Liang
, Michitoshi Hayashi
, Ying Jen Shiu
, Yan Mo
, Jiushu Shao
, Yijing Yan
, Sheng Hsien Lin

Academia Sinica - Institute of Atomic and Molecular Sciences
National Taiwan University
Hong Kong University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.

源语言	英语
页（从-至）	335-338
页数	4
期刊	Journal of the Chinese Chemical Society
卷	50
期	3 A
DOI	https://doi.org/10.1002/jccs.200300050
出版状态	已出版 - 2003
已对外发布	是

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title = "Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding",

abstract = "The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.",

keywords = "Density matrix method, Generalized kinetic king model, Mean field theory, Protein folding",

author = "Liang, \{Kuo Kan\} and Michitoshi Hayashi and Shiu, \{Ying Jen\} and Yan Mo and Jiushu Shao and Yijing Yan and Lin, \{Sheng Hsien\}",

year = "2003",

doi = "10.1002/jccs.200300050",

language = "英语",

volume = "50",

pages = "335--338",

journal = "Journal of the Chinese Chemical Society",

issn = "0009-4536",

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TY - JOUR

T1 - Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

AU - Liang, Kuo Kan

AU - Hayashi, Michitoshi

AU - Shiu, Ying Jen

AU - Mo, Yan

AU - Shao, Jiushu

AU - Yan, Yijing

AU - Lin, Sheng Hsien

PY - 2003

Y1 - 2003

N2 - The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.

AB - The kinetic Ising model in the mean field approximation has been applied to study the equilibrium and kinetic behaviors of protein folding-unfolding. Thermodynamics and kinetics of protein folding-unfolding are related by an elementary process of folding ↔ unfolding of peptide bonds. As a demonstration, we analyze, using the presented theory, the equilibrium and kinetics properties of Leu94Val mutant of horse cyt. c (Biochemistry 35, 5538 (1996).) and several characteristic properties are deduced using our theoretical model.

KW - Density matrix method

KW - Generalized kinetic king model

KW - Mean field theory

KW - Protein folding

UR - https://www.scopus.com/pages/publications/33746075741

U2 - 10.1002/jccs.200300050

DO - 10.1002/jccs.200300050

M3 - 文章

AN - SCOPUS:33746075741

SN - 0009-4536

VL - 50

SP - 335

EP - 338

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 3 A

ER -

Application of the Generalized Kinetic Ising Model to the Kinetics of Protein Folding

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