TY - JOUR
T1 - An efficient Ir(III) catalyst for the asymmetric transfer hydrogenation of ketones in neat water
AU - Li, Xiaohong
AU - Blacker, John
AU - Houson, Ian
AU - Wu, Xiaofeng
AU - Xiao, Jianliang
PY - 2006/5/15
Y1 - 2006/5/15
N2 - The chiral M-CsDPEN [M = Ru, Rh, Ir; CsDPEN = (R,R,R)- or (S,S,S)-N-camphorsulfonyl-1,2-diphenylethylenediamine] catalysts have been shown to be efficient for the asymmetric transfer hydrogenation (ATH) of aryl ketones by formate in neat water. Of particular note is the Ir-(R,R,R)-CsDPEN catalyst, which catalyzes the ATH of a wide range of ketones and delivers almost full conversions within a few hours at a S/C ratio of 1000 at 40 °C in most cases, with enantioselectivities up to 98% ee.
AB - The chiral M-CsDPEN [M = Ru, Rh, Ir; CsDPEN = (R,R,R)- or (S,S,S)-N-camphorsulfonyl-1,2-diphenylethylenediamine] catalysts have been shown to be efficient for the asymmetric transfer hydrogenation (ATH) of aryl ketones by formate in neat water. Of particular note is the Ir-(R,R,R)-CsDPEN catalyst, which catalyzes the ATH of a wide range of ketones and delivers almost full conversions within a few hours at a S/C ratio of 1000 at 40 °C in most cases, with enantioselectivities up to 98% ee.
KW - Asymmetric transfer hydrogenation
KW - Camphor ligand
KW - Formate
KW - Ketones
KW - Water
UR - https://www.scopus.com/pages/publications/33744491804
U2 - 10.1055/s-2006-932490
DO - 10.1055/s-2006-932490
M3 - 文章
AN - SCOPUS:33744491804
SN - 0936-5214
SP - 1155
EP - 1160
JO - Synlett
JF - Synlett
IS - 8
ER -