An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

Meihua Yu; Yuting Niu; Yannan Yang; Sandy Budi Hartono; Jie Yang; Xiaodan Huang; Peter Thorn; Chengzhong Yu

doi:10.1021/am503060n

An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

Meihua Yu
, Yuting Niu
, Yannan Yang
, Sandy Budi Hartono
, Jie Yang
, Xiaodan Huang
, Peter Thorn
, Chengzhong Yu^*

^*此作品的通讯作者

University of Queensland

科研成果: 期刊稿件 › 文章 › 同行评审

20 引用（Scopus）

摘要

A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

源语言	英语
页（从-至）	15626-15631
页数	6
期刊	ACS Applied Materials and Interfaces
卷	6
期	18
DOI	https://doi.org/10.1021/am503060n
出版状态	已出版 - 24 9月 2014
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1021/am503060n

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引用此

@article{bf89df6ffe5c404b862ef711b7d5073d,

title = "An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery",

abstract = "A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.",

keywords = "Gene delivery, Polyethylenimine, SiRNA, Silica nanoparticles, Surface modification",

author = "Meihua Yu and Yuting Niu and Yannan Yang and Hartono, \{Sandy Budi\} and Jie Yang and Xiaodan Huang and Peter Thorn and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

month = sep,

day = "24",

doi = "10.1021/am503060n",

language = "英语",

volume = "6",

pages = "15626--15631",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

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number = "18",

}

TY - JOUR

T1 - An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

AU - Yu, Meihua

AU - Niu, Yuting

AU - Yang, Yannan

AU - Hartono, Sandy Budi

AU - Yang, Jie

AU - Huang, Xiaodan

AU - Thorn, Peter

AU - Yu, Chengzhong

PY - 2014/9/24

Y1 - 2014/9/24

N2 - A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

AB - A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

KW - Gene delivery

KW - Polyethylenimine

KW - SiRNA

KW - Silica nanoparticles

KW - Surface modification

UR - https://www.scopus.com/pages/publications/84912048749

U2 - 10.1021/am503060n

DO - 10.1021/am503060n

M3 - 文章

C2 - 25184370

AN - SCOPUS:84912048749

SN - 1944-8244

VL - 6

SP - 15626

EP - 15631

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 18

ER -

An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

摘要

联合国可持续发展目标

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