Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

Wen Wei Qiu; Jie Xu; Jing Ya Li; Jia Li; Fa Jun Nan

doi:10.1002/cbic.200700148

Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

Wen Wei Qiu
, Jie Xu
, Jing Ya Li
, Jia Li^*
, Fa Jun Nan

^*此作品的通讯作者

CAS - Shanghai Institute of Materia Medica

科研成果: 期刊稿件 › 文章 › 同行评审

25 引用（Scopus）

摘要

(Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.

源语言	英语
页（从-至）	1351-1358
页数	8
期刊	ChemBioChem
卷	8
期	12
DOI	https://doi.org/10.1002/cbic.200700148
出版状态	已出版 - 13 8月 2007
已对外发布	是

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10.1002/cbic.200700148

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title = "Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes",

abstract = "(Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.",

keywords = "Azido-acetyl group, Molecular recognition, Photoaffinity labeling, Protein profiling, Trimodular probes",

author = "Qiu, \{Wen Wei\} and Jie Xu and Li, \{Jing Ya\} and Jia Li and Nan, \{Fa Jun\}",

year = "2007",

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T1 - Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

AU - Qiu, Wen Wei

AU - Xu, Jie

AU - Li, Jing Ya

AU - Li, Jia

AU - Nan, Fa Jun

PY - 2007/8/13

Y1 - 2007/8/13

N2 - (Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.

AB - (Chemical Equation Presented) Three in one. A trimodular probe (1) with three functional groups (for target recognition, proximal target crosslinking, and distal reporter tag attachment via click chemistry of a photostable azido-acetyl group) has been designed. We demonstrate its specificity, sensitivity, and potential for general application in activity-based protein profiling for type I methionine aminopeptidases.

KW - Azido-acetyl group

KW - Molecular recognition

KW - Photoaffinity labeling

KW - Protein profiling

KW - Trimodular probes

UR - https://www.scopus.com/pages/publications/34548118304

U2 - 10.1002/cbic.200700148

DO - 10.1002/cbic.200700148

M3 - 文章

C2 - 17623306

AN - SCOPUS:34548118304

SN - 1439-4227

VL - 8

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EP - 1358

JO - ChemBioChem

JF - ChemBioChem

IS - 12

ER -

Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes

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