Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

Ping Yu; Shou De Zhang; Yong Li Li; Xian Wen Yang; Hua Wu Zeng; Hong Lin Li; Wei Dong Zhang

doi:10.1002/hlca.201100341

Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

Ping Yu
, Shou De Zhang
, Yong Li Li
, Xian Wen Yang^*
, Hua Wu Zeng
, Hong Lin Li
, Wei Dong Zhang

^*此作品的通讯作者

Naval Medical University
Shanghai Jiao Tong University
Chinese Academy of Sciences
East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

7 引用（Scopus）

摘要

A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.

源语言	英语
页（从-至）	415-422
页数	8
期刊	Helvetica Chimica Acta
卷	95
期	3
DOI	https://doi.org/10.1002/hlca.201100341
出版状态	已出版 - 3月 2012
已对外发布	是

访问文件

10.1002/hlca.201100341

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{9d6fe1edcf0d4d61bcee763fc76f2bcc,

title = "Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii",

abstract = "A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.",

keywords = "Abies forrestii, Abieseconordines A and B, Density-functional theory (DFT), Ditepenoids, Electronic circular dichroism (ECD), Nitric oxide",

author = "Ping Yu and Zhang, \{Shou De\} and Li, \{Yong Li\} and Yang, \{Xian Wen\} and Zeng, \{Hua Wu\} and Li, \{Hong Lin\} and Zhang, \{Wei Dong\}",

year = "2012",

month = mar,

doi = "10.1002/hlca.201100341",

language = "英语",

volume = "95",

pages = "415--422",

journal = "Helvetica Chimica Acta",

issn = "0018-019X",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

AU - Yu, Ping

AU - Zhang, Shou De

AU - Li, Yong Li

AU - Yang, Xian Wen

AU - Zeng, Hua Wu

AU - Li, Hong Lin

AU - Zhang, Wei Dong

PY - 2012/3

Y1 - 2012/3

N2 - A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.

AB - A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages.

KW - Abies forrestii

KW - Abieseconordines A and B

KW - Density-functional theory (DFT)

KW - Ditepenoids

KW - Electronic circular dichroism (ECD)

KW - Nitric oxide

UR - https://www.scopus.com/pages/publications/84859084910

U2 - 10.1002/hlca.201100341

DO - 10.1002/hlca.201100341

M3 - 文章

AN - SCOPUS:84859084910

SN - 0018-019X

VL - 95

SP - 415

EP - 422

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 3

ER -

Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

摘要

访问文件

其它文件与链接

指纹

引用此