A two-channel ratiometric electrochemical biosensor for in vivo monitoring of copper ions in a rat brain using gold truncated octahedral microcages

Brain chemistry: A biosensor has been developed for in vivo determination of copper ions in a rat brain by using gold truncated octahedral microcages. The significant analytical performance of the present biosensor, as well as the properties of a carbon fiber microelectrode have provided a direct and reliable approach for monitoring cerebral metal ions (W.E.=working electrode; see picture).