A transformation of cyclopropyl carbene: A highly enantioselective three-component reaction via trapping oxonium ylide by imine

Mingfeng Li; Qing Zheng; Weifeng Jin; Shunying Liu; Wenhao Hu

doi:10.1016/j.tet.2016.04.006

A transformation of cyclopropyl carbene: A highly enantioselective three-component reaction via trapping oxonium ylide by imine

Mingfeng Li
, Qing Zheng
, Weifeng Jin
, Shunying Liu^*
, Wenhao Hu

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

A transformation of cyclopropyl carbene generated from 2-cyclopropyl-2-diazoacetate via oxonium ylide was found by trapping the resulting ylide with imine. The asymmetric three-component reaction of cycloproyl diazoacetates, benzenemethanols and imines afforded a rapid and efficient method to synthesize complex cyclopropane derivatives with excellent diastereoselectivity and enantioselectivity.

源语言	英语
页（从-至）	2929-2934
页数	6
期刊	Tetrahedron
卷	72
期	22
DOI	https://doi.org/10.1016/j.tet.2016.04.006
出版状态	已出版 - 2 6月 2016

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10.1016/j.tet.2016.04.006

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title = "A transformation of cyclopropyl carbene: A highly enantioselective three-component reaction via trapping oxonium ylide by imine",

abstract = "A transformation of cyclopropyl carbene generated from 2-cyclopropyl-2-diazoacetate via oxonium ylide was found by trapping the resulting ylide with imine. The asymmetric three-component reaction of cycloproyl diazoacetates, benzenemethanols and imines afforded a rapid and efficient method to synthesize complex cyclopropane derivatives with excellent diastereoselectivity and enantioselectivity.",

keywords = "Asymmetric catalysis, Diazocyclopropane, Metal carbene, Oxonium ylide, Three-component reaction",

author = "Mingfeng Li and Qing Zheng and Weifeng Jin and Shunying Liu and Wenhao Hu",

year = "2016",

month = jun,

day = "2",

doi = "10.1016/j.tet.2016.04.006",

language = "英语",

volume = "72",

pages = "2929--2934",

journal = "Tetrahedron",

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TY - JOUR

T1 - A transformation of cyclopropyl carbene

T2 - A highly enantioselective three-component reaction via trapping oxonium ylide by imine

AU - Li, Mingfeng

AU - Zheng, Qing

AU - Jin, Weifeng

AU - Liu, Shunying

AU - Hu, Wenhao

PY - 2016/6/2

Y1 - 2016/6/2

N2 - A transformation of cyclopropyl carbene generated from 2-cyclopropyl-2-diazoacetate via oxonium ylide was found by trapping the resulting ylide with imine. The asymmetric three-component reaction of cycloproyl diazoacetates, benzenemethanols and imines afforded a rapid and efficient method to synthesize complex cyclopropane derivatives with excellent diastereoselectivity and enantioselectivity.

AB - A transformation of cyclopropyl carbene generated from 2-cyclopropyl-2-diazoacetate via oxonium ylide was found by trapping the resulting ylide with imine. The asymmetric three-component reaction of cycloproyl diazoacetates, benzenemethanols and imines afforded a rapid and efficient method to synthesize complex cyclopropane derivatives with excellent diastereoselectivity and enantioselectivity.

KW - Asymmetric catalysis

KW - Diazocyclopropane

KW - Metal carbene

KW - Oxonium ylide

KW - Three-component reaction

UR - https://www.scopus.com/pages/publications/84963956548

U2 - 10.1016/j.tet.2016.04.006

DO - 10.1016/j.tet.2016.04.006

M3 - 文章

AN - SCOPUS:84963956548

SN - 0040-4020

VL - 72

SP - 2929

EP - 2934

JO - Tetrahedron

JF - Tetrahedron

IS - 22

ER -

A transformation of cyclopropyl carbene: A highly enantioselective three-component reaction via trapping oxonium ylide by imine

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