A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade

Karavadhi Surendra; Wenwei Qiu; E. J. Corey

doi:10.1021/ja204142n

A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade

Karavadhi Surendra
, Wenwei Qiu
, E. J. Corey

Harvard University

科研成果: 期刊稿件 › 文章 › 同行评审

86 引用（Scopus）

摘要

InI₃ and InBr₃ have been found to be effective catalysts for the π activation of C≡C bonds to initiate the conversion of chiral propargylic alcohols or silyl ethers to polycyclic products in excellent yields and with high stereoselectivity. The method has been applied to the synthesis of chiral fused hexacyclic ring systems with the creation of multiple new stereocenters. The power and scope of the method are illustrated by a variety of examples.

源语言	英语
页（从-至）	9724-9726
页数	3
期刊	Journal of the American Chemical Society
卷	133
期	25
DOI	https://doi.org/10.1021/ja204142n
出版状态	已出版 - 29 6月 2011
已对外发布	是

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N2 - InI3 and InBr3 have been found to be effective catalysts for the π activation of C≡C bonds to initiate the conversion of chiral propargylic alcohols or silyl ethers to polycyclic products in excellent yields and with high stereoselectivity. The method has been applied to the synthesis of chiral fused hexacyclic ring systems with the creation of multiple new stereocenters. The power and scope of the method are illustrated by a variety of examples.

AB - InI3 and InBr3 have been found to be effective catalysts for the π activation of C≡C bonds to initiate the conversion of chiral propargylic alcohols or silyl ethers to polycyclic products in excellent yields and with high stereoselectivity. The method has been applied to the synthesis of chiral fused hexacyclic ring systems with the creation of multiple new stereocenters. The power and scope of the method are illustrated by a variety of examples.

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A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade

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