A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

Chaoqian Huang; Yu Zeng; Huayu Cheng; Anjing Hu; Lu Liu; Yuanjing Xiao; Junliang Zhang

doi:10.1021/acs.orglett.7b02427

A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

Chaoqian Huang
, Yu Zeng
, Huayu Cheng
, Anjing Hu
, Lu Liu
, Yuanjing Xiao^*
, Junliang Zhang

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

59 引用（Scopus）

摘要

An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination product. The salient features of this method include mild conditions, readily available starting materials, general substrate scope, high efficiency and synthetic utility of the products.

源语言	英语
页（从-至）	4968-4971
页数	4
期刊	Organic Letters
卷	19
期	18
DOI	https://doi.org/10.1021/acs.orglett.7b02427
出版状态	已出版 - 15 9月 2017

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10.1021/acs.orglett.7b02427

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abstract = "An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination product. The salient features of this method include mild conditions, readily available starting materials, general substrate scope, high efficiency and synthetic utility of the products.",

author = "Chaoqian Huang and Yu Zeng and Huayu Cheng and Anjing Hu and Lu Liu and Yuanjing Xiao and Junliang Zhang",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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T1 - A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

AU - Huang, Chaoqian

AU - Zeng, Yu

AU - Cheng, Huayu

AU - Hu, Anjing

AU - Liu, Lu

AU - Xiao, Yuanjing

AU - Zhang, Junliang

PY - 2017/9/15

Y1 - 2017/9/15

N2 - An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination product. The salient features of this method include mild conditions, readily available starting materials, general substrate scope, high efficiency and synthetic utility of the products.

AB - An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination product. The salient features of this method include mild conditions, readily available starting materials, general substrate scope, high efficiency and synthetic utility of the products.

UR - https://www.scopus.com/pages/publications/85029541338

U2 - 10.1021/acs.orglett.7b02427

DO - 10.1021/acs.orglett.7b02427

M3 - 文章

C2 - 28862450

AN - SCOPUS:85029541338

SN - 1523-7060

VL - 19

SP - 4968

EP - 4971

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

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