A novel GAP460 biopolymer for use as a carrier in drug-delivery applications

Zhen Feng; Wenjuan Li; Xiaomin Xue; Xu Geng; Yelin Wu; Jing Huang; Zirong Wu

doi:10.1163/092050610X530973

A novel GAP460 biopolymer for use as a carrier in drug-delivery applications

Zhen Feng
, Wenjuan Li
, Xiaomin Xue
, Xu Geng
, Yelin Wu
, Jing Huang
, Zirong Wu^*

^*此作品的通讯作者

生命科学学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

5 引用（Scopus）

摘要

We synthesized a new non-toxic biopolymer (GAP460) containing γ,L-glutamic acid and aspartate (Asp). Conjugates of GAP460 and cisplatin exhibited a drug-carrying capacity of nearly 40%, 3-times higher than γ-PGA and dramatically decreasing the amount of biopolymer required for high-dose delivery. Treatment with GAP460-cisplatin conjugate (PACC) not only effectively inhibited tumor growth in nude mice, but also resulted in extended survival and lower nephrotoxicity, suggesting that GAP460 could be used as an effective carrier for drug delivery and that PACC may have potential therapeutic applications in the clinical treatment of cancer.

源语言	英语
页（从-至）	2023-2040
页数	18
期刊	Journal of Biomaterials Science, Polymer Edition
卷	22
期	15
DOI	https://doi.org/10.1163/092050610X530973
出版状态	已出版 - 2011

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1163/092050610X530973

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引用此

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title = "A novel GAP460 biopolymer for use as a carrier in drug-delivery applications",

abstract = "We synthesized a new non-toxic biopolymer (GAP460) containing γ,L-glutamic acid and aspartate (Asp). Conjugates of GAP460 and cisplatin exhibited a drug-carrying capacity of nearly 40\%, 3-times higher than γ-PGA and dramatically decreasing the amount of biopolymer required for high-dose delivery. Treatment with GAP460-cisplatin conjugate (PACC) not only effectively inhibited tumor growth in nude mice, but also resulted in extended survival and lower nephrotoxicity, suggesting that GAP460 could be used as an effective carrier for drug delivery and that PACC may have potential therapeutic applications in the clinical treatment of cancer.",

keywords = "Poly(γ,L-glutamic acid), aspartate conjugate, cisplatin, drug delivery, toxicity",

author = "Zhen Feng and Wenjuan Li and Xiaomin Xue and Xu Geng and Yelin Wu and Jing Huang and Zirong Wu",

year = "2011",

doi = "10.1163/092050610X530973",

language = "英语",

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T1 - A novel GAP460 biopolymer for use as a carrier in drug-delivery applications

AU - Feng, Zhen

AU - Li, Wenjuan

AU - Xue, Xiaomin

AU - Geng, Xu

AU - Wu, Yelin

AU - Huang, Jing

AU - Wu, Zirong

PY - 2011

Y1 - 2011

N2 - We synthesized a new non-toxic biopolymer (GAP460) containing γ,L-glutamic acid and aspartate (Asp). Conjugates of GAP460 and cisplatin exhibited a drug-carrying capacity of nearly 40%, 3-times higher than γ-PGA and dramatically decreasing the amount of biopolymer required for high-dose delivery. Treatment with GAP460-cisplatin conjugate (PACC) not only effectively inhibited tumor growth in nude mice, but also resulted in extended survival and lower nephrotoxicity, suggesting that GAP460 could be used as an effective carrier for drug delivery and that PACC may have potential therapeutic applications in the clinical treatment of cancer.

AB - We synthesized a new non-toxic biopolymer (GAP460) containing γ,L-glutamic acid and aspartate (Asp). Conjugates of GAP460 and cisplatin exhibited a drug-carrying capacity of nearly 40%, 3-times higher than γ-PGA and dramatically decreasing the amount of biopolymer required for high-dose delivery. Treatment with GAP460-cisplatin conjugate (PACC) not only effectively inhibited tumor growth in nude mice, but also resulted in extended survival and lower nephrotoxicity, suggesting that GAP460 could be used as an effective carrier for drug delivery and that PACC may have potential therapeutic applications in the clinical treatment of cancer.

KW - Poly(γ,L-glutamic acid)

KW - aspartate conjugate

KW - cisplatin

KW - drug delivery

KW - toxicity

UR - https://www.scopus.com/pages/publications/80052076111

U2 - 10.1163/092050610X530973

DO - 10.1163/092050610X530973

M3 - 文章

C2 - 21029517

AN - SCOPUS:80052076111

SN - 0920-5063

VL - 22

SP - 2023

EP - 2040

JO - Journal of Biomaterials Science, Polymer Edition

JF - Journal of Biomaterials Science, Polymer Edition

IS - 15

ER -

A novel GAP460 biopolymer for use as a carrier in drug-delivery applications

摘要

联合国可持续发展目标

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