A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products

Nianjin Liu; Song Cao; Jingjing Wu; Li Shen; Jinlong Yu; Jian Zhang; Hui Li; Xuhong Qian

doi:10.1007/s11030-009-9209-x

A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products

Nianjin Liu
, Song Cao^*
, Jingjing Wu
, Li Shen
, Jinlong Yu
, Jian Zhang
, Hui Li
, Xuhong Qian

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.

源语言	英语
页（从-至）	501-506
页数	6
期刊	Molecular Diversity
卷	14
期	3
DOI	https://doi.org/10.1007/s11030-009-9209-x
出版状态	已出版 - 8月 2010
已对外发布	是

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title = "A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products",

abstract = "Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.",

keywords = "Dehydrofluorination, Monofluorinated α-lactam pseudopeptide, Ugi reaction",

author = "Nianjin Liu and Song Cao and Jingjing Wu and Li Shen and Jinlong Yu and Jian Zhang and Hui Li and Xuhong Qian",

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AU - Liu, Nianjin

AU - Cao, Song

AU - Wu, Jingjing

AU - Shen, Li

AU - Yu, Jinlong

AU - Zhang, Jian

AU - Li, Hui

AU - Qian, Xuhong

PY - 2010/8

Y1 - 2010/8

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AB - Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.

KW - Dehydrofluorination

KW - Monofluorinated α-lactam pseudopeptide

KW - Ugi reaction

UR - https://www.scopus.com/pages/publications/78650171113

U2 - 10.1007/s11030-009-9209-x

DO - 10.1007/s11030-009-9209-x

M3 - 文章

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AN - SCOPUS:78650171113

SN - 1381-1991

VL - 14

SP - 501

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A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products

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