A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

Jun Yuan; Yu Qiong Xu; Nan Nan Zhou; Rui Wang; Xu Hong Qian; Yu Fang Xu

doi:10.1039/c4ra10044a

A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

Jun Yuan
, Yu Qiong Xu
, Nan Nan Zhou
, Rui Wang
, Xu Hong Qian
, Yu Fang Xu^*

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

46 引用（Scopus）

摘要

Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

源语言	英语
页（从-至）	56207-56210
页数	4
期刊	RSC Advances
卷	4
期	99
DOI	https://doi.org/10.1039/c4ra10044a
出版状态	已出版 - 2014
已对外发布	是

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title = "A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging",

abstract = "Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.",

author = "Jun Yuan and Xu, \{Yu Qiong\} and Zhou, \{Nan Nan\} and Rui Wang and Qian, \{Xu Hong\} and Xu, \{Yu Fang\}",

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year = "2014",

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T1 - A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

AU - Yuan, Jun

AU - Xu, Yu Qiong

AU - Zhou, Nan Nan

AU - Wang, Rui

AU - Qian, Xu Hong

AU - Xu, Yu Fang

PY - 2014

Y1 - 2014

N2 - Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

AB - Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

UR - https://www.scopus.com/pages/publications/84908616802

U2 - 10.1039/c4ra10044a

DO - 10.1039/c4ra10044a

M3 - 文章

AN - SCOPUS:84908616802

SN - 2046-2069

VL - 4

SP - 56207

EP - 56210

JO - RSC Advances

JF - RSC Advances

IS - 99

ER -

A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

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