A conserved ion channel function of STING mediates noncanonical autophagy and cell death

Jinrui Xun; Zhichao Zhang; Bo Lv; Defen Lu; Haoxiang Yang; Guijun Shang; Jay Xiaojun Tan

doi:10.1038/s44319-023-00045-x

A conserved ion channel function of STING mediates noncanonical autophagy and cell death

Jinrui Xun
, Zhichao Zhang
, Bo Lv
, Defen Lu
, Haoxiang Yang
, Guijun Shang^*
, Jay Xiaojun Tan^*

^*此作品的通讯作者

Central South University
University of Pittsburgh
Shanxi Agricultural University
Shanxi University
SAARI

科研成果: 期刊稿件 › 文章 › 同行评审

73 引用（Scopus）

摘要

Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)

源语言	英语
页（从-至）	544-569
页数	26
期刊	EMBO Reports
卷	25
期	2
DOI	https://doi.org/10.1038/s44319-023-00045-x
出版状态	已出版 - 13 2月 2024
已对外发布	是

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title = "A conserved ion channel function of STING mediates noncanonical autophagy and cell death",

abstract = "Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)",

keywords = "Ion Channel, Membrane Trafficking, Noncanonical Autophagy, STING, Vesicle Deacidification",

author = "Jinrui Xun and Zhichao Zhang and Bo Lv and Defen Lu and Haoxiang Yang and Guijun Shang and Tan, \{Jay Xiaojun\}",

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T1 - A conserved ion channel function of STING mediates noncanonical autophagy and cell death

AU - Xun, Jinrui

AU - Zhang, Zhichao

AU - Lv, Bo

AU - Lu, Defen

AU - Yang, Haoxiang

AU - Shang, Guijun

AU - Tan, Jay Xiaojun

N1 - Publisher Copyright: © The Author(s) 2024..

PY - 2024/2/13

Y1 - 2024/2/13

N2 - Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)

AB - Activated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single membranes (CASM) and cell death. (Figure presented.)

KW - Ion Channel

KW - Membrane Trafficking

KW - Noncanonical Autophagy

KW - STING

KW - Vesicle Deacidification

UR - https://www.scopus.com/pages/publications/85185198461

U2 - 10.1038/s44319-023-00045-x

DO - 10.1038/s44319-023-00045-x

M3 - 文章

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AN - SCOPUS:85185198461

SN - 1469-221X

VL - 25

SP - 544

EP - 569

JO - EMBO Reports

JF - EMBO Reports

IS - 2

ER -

A conserved ion channel function of STING mediates noncanonical autophagy and cell death

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