1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

Zhi Fu Tao; Xuhong Qian; Dongzhi Wei

doi:10.1016/0143-7208(95)00105-0

1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

Zhi Fu Tao
, Xuhong Qian^*
, Dongzhi Wei

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

19 引用（Scopus）

摘要

Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.

源语言	英语
页（从-至）	245-251
页数	7
期刊	Dyes and Pigments
卷	31
期	3
DOI	https://doi.org/10.1016/0143-7208(95)00105-0
出版状态	已出版 - 7月 1996
已对外发布	是

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title = "1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers",

abstract = "Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.",

author = "Tao, \{Zhi Fu\} and Xuhong Qian and Dongzhi Wei",

year = "1996",

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T1 - 1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

AU - Tao, Zhi Fu

AU - Qian, Xuhong

AU - Wei, Dongzhi

PY - 1996/7

Y1 - 1996/7

N2 - Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.

AB - Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.

UR - https://www.scopus.com/pages/publications/0030194657

U2 - 10.1016/0143-7208(95)00105-0

DO - 10.1016/0143-7208(95)00105-0

M3 - 文章

AN - SCOPUS:0030194657

SN - 0143-7208

VL - 31

SP - 245

EP - 251

JO - Dyes and Pigments

JF - Dyes and Pigments

IS - 3

ER -

1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

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