含藜芦酸单元的马蹄金素衍生物的合成及其抗HBV活性研究

An Xiang Kuang; Wei Lu; Xiao Ping Zeng; Guang Yi Liang; Bi Xue Xu

含藜芦酸单元的马蹄金素衍生物的合成及其抗HBV活性研究

An Xiang Kuang
, Wei Lu
, Xiao Ping Zeng
, Guang Yi Liang^*
, Bi Xue Xu

^*此作品的通讯作者

Guizhou University of Traditional Chinese Medicine
Guizhou Medical University
Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

Objective: To design, synthesize and biological evaluate a series of new derivatives of Matijin-Su (MTS). Methods: By using MTS as a lead compound, a series of MTS derivatives containing veratric acid were designed and synthesized and their structures were confirmed by NMR and ESI-MS. The anti-HBV activities of those target compounds were evaluated in in vitro cells. Results: Twenty new MTS derivatives containing veratric acid group were designed and synthesized and their anti-HBV activity evaluation were carried out. Compounds 23, 24 and 25 exhibited effective activities against the replication of HBV DNA with IC₅₀ values of 6.17, 9.18 and 8.29 μmol•L^-1 respectively. Conclusion: The MTS derivatives with veratric acid have the value of further research.

投稿的翻译标题	Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing veratric acid
源语言	繁体中文
页（从-至）	1523-1530
页数	8
期刊	Chinese Journal of New Drugs
卷	28
期	12
出版状态	已出版 - 30 6月 2019
已对外发布	是

关键词

Anti-HBV activity
Derivative of Matijin-Su
Synthesis
Veratric acid

其它文件与链接

链接到 Scopus 的出版物

引用此

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title = "含藜芦酸单元的马蹄金素衍生物的合成及其抗HBV活性研究",

abstract = "Objective: To design, synthesize and biological evaluate a series of new derivatives of Matijin-Su (MTS). Methods: By using MTS as a lead compound, a series of MTS derivatives containing veratric acid were designed and synthesized and their structures were confirmed by NMR and ESI-MS. The anti-HBV activities of those target compounds were evaluated in in vitro cells. Results: Twenty new MTS derivatives containing veratric acid group were designed and synthesized and their anti-HBV activity evaluation were carried out. Compounds 23, 24 and 25 exhibited effective activities against the replication of HBV DNA with IC50 values of 6.17, 9.18 and 8.29 μmol•L-1 respectively. Conclusion: The MTS derivatives with veratric acid have the value of further research.",

keywords = "Anti-HBV activity, Derivative of Matijin-Su, Synthesis, Veratric acid",

author = "Kuang, \{An Xiang\} and Wei Lu and Zeng, \{Xiao Ping\} and Liang, \{Guang Yi\} and Xu, \{Bi Xue\}",

year = "2019",

month = jun,

day = "30",

language = "繁体中文",

volume = "28",

pages = "1523--1530",

journal = "Chinese Journal of New Drugs",

issn = "1003-3734",

publisher = "Chinese Journal of New Drugs Co. Ltd.",

number = "12",

}

TY - JOUR

T1 - 含藜芦酸单元的马蹄金素衍生物的合成及其抗HBV活性研究

AU - Kuang, An Xiang

AU - Lu, Wei

AU - Zeng, Xiao Ping

AU - Liang, Guang Yi

AU - Xu, Bi Xue

PY - 2019/6/30

Y1 - 2019/6/30

N2 - Objective: To design, synthesize and biological evaluate a series of new derivatives of Matijin-Su (MTS). Methods: By using MTS as a lead compound, a series of MTS derivatives containing veratric acid were designed and synthesized and their structures were confirmed by NMR and ESI-MS. The anti-HBV activities of those target compounds were evaluated in in vitro cells. Results: Twenty new MTS derivatives containing veratric acid group were designed and synthesized and their anti-HBV activity evaluation were carried out. Compounds 23, 24 and 25 exhibited effective activities against the replication of HBV DNA with IC50 values of 6.17, 9.18 and 8.29 μmol•L-1 respectively. Conclusion: The MTS derivatives with veratric acid have the value of further research.

AB - Objective: To design, synthesize and biological evaluate a series of new derivatives of Matijin-Su (MTS). Methods: By using MTS as a lead compound, a series of MTS derivatives containing veratric acid were designed and synthesized and their structures were confirmed by NMR and ESI-MS. The anti-HBV activities of those target compounds were evaluated in in vitro cells. Results: Twenty new MTS derivatives containing veratric acid group were designed and synthesized and their anti-HBV activity evaluation were carried out. Compounds 23, 24 and 25 exhibited effective activities against the replication of HBV DNA with IC50 values of 6.17, 9.18 and 8.29 μmol•L-1 respectively. Conclusion: The MTS derivatives with veratric acid have the value of further research.

KW - Anti-HBV activity

KW - Derivative of Matijin-Su

KW - Synthesis

KW - Veratric acid

UR - https://www.scopus.com/pages/publications/85070493755

M3 - 文章

AN - SCOPUS:85070493755

SN - 1003-3734

VL - 28

SP - 1523

EP - 1530

JO - Chinese Journal of New Drugs

JF - Chinese Journal of New Drugs

IS - 12

ER -

含藜芦酸单元的马蹄金素衍生物的合成及其抗HBV活性研究

摘要

关键词

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