ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway

Jing Li; Yuequn Wang; Xiongwei Fan; Xiaoyang Mo; Zequn Wang; Yongqing Li; Zhaochu Yin; Yun Deng; Na Luo; Chuanbing Zhu; Mingyao Liu; Qian Ma; Karen Ocorr; Wuzhou Yuan; Xiushan Wu

doi:10.1016/j.bbrc.2007.08.180

ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway

Jing Li, Yuequn Wang, Xiongwei Fan, Xiaoyang Mo, Zequn Wang, Yongqing Li, Zhaochu Yin, Yun Deng, Na Luo, Chuanbing Zhu, Mingyao Liu, Qian Ma, Karen Ocorr, Wuzhou Yuan, Xiushan Wu

College of Life Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We have cloned a novel KRAB-related zinc finger gene, ZNF307, encoding a protein of 545 aa. ZNF307 is conserved across species in evolution and is differentially expressed in human adult and fetal tissues. The fusion protein of EGFP-ZNF307 localizes in the nucleus. Transcriptional activity assays show ZNF307 suppresses transcriptional activity of L8G5-luciferase. Overexpressing ZNF307 in different cell lines also inhibits the transcriptional activities of p53 and p21. Moreover, ZNF307 works by reducing the p53 protein level and p53 protein reduction is achieved by increasing transcription of MDM2 and EP300. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation.

Original language	English
Pages (from-to)	895-900
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	363
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2007.08.180
State	Published - 30 Nov 2007
Externally published	Yes

Keywords

KRAB
ZNF307
p21
p53

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10.1016/j.bbrc.2007.08.180

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title = "ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway",

abstract = "We have cloned a novel KRAB-related zinc finger gene, ZNF307, encoding a protein of 545 aa. ZNF307 is conserved across species in evolution and is differentially expressed in human adult and fetal tissues. The fusion protein of EGFP-ZNF307 localizes in the nucleus. Transcriptional activity assays show ZNF307 suppresses transcriptional activity of L8G5-luciferase. Overexpressing ZNF307 in different cell lines also inhibits the transcriptional activities of p53 and p21. Moreover, ZNF307 works by reducing the p53 protein level and p53 protein reduction is achieved by increasing transcription of MDM2 and EP300. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation.",

keywords = "KRAB, ZNF307, p21, p53",

author = "Jing Li and Yuequn Wang and Xiongwei Fan and Xiaoyang Mo and Zequn Wang and Yongqing Li and Zhaochu Yin and Yun Deng and Na Luo and Chuanbing Zhu and Mingyao Liu and Qian Ma and Karen Ocorr and Wuzhou Yuan and Xiushan Wu",

year = "2007",

month = nov,

day = "30",

doi = "10.1016/j.bbrc.2007.08.180",

language = "英语",

volume = "363",

pages = "895--900",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway

AU - Li, Jing

AU - Wang, Yuequn

AU - Fan, Xiongwei

AU - Mo, Xiaoyang

AU - Wang, Zequn

AU - Li, Yongqing

AU - Yin, Zhaochu

AU - Deng, Yun

AU - Luo, Na

AU - Zhu, Chuanbing

AU - Liu, Mingyao

AU - Ma, Qian

AU - Ocorr, Karen

AU - Yuan, Wuzhou

AU - Wu, Xiushan

PY - 2007/11/30

Y1 - 2007/11/30

N2 - We have cloned a novel KRAB-related zinc finger gene, ZNF307, encoding a protein of 545 aa. ZNF307 is conserved across species in evolution and is differentially expressed in human adult and fetal tissues. The fusion protein of EGFP-ZNF307 localizes in the nucleus. Transcriptional activity assays show ZNF307 suppresses transcriptional activity of L8G5-luciferase. Overexpressing ZNF307 in different cell lines also inhibits the transcriptional activities of p53 and p21. Moreover, ZNF307 works by reducing the p53 protein level and p53 protein reduction is achieved by increasing transcription of MDM2 and EP300. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation.

AB - We have cloned a novel KRAB-related zinc finger gene, ZNF307, encoding a protein of 545 aa. ZNF307 is conserved across species in evolution and is differentially expressed in human adult and fetal tissues. The fusion protein of EGFP-ZNF307 localizes in the nucleus. Transcriptional activity assays show ZNF307 suppresses transcriptional activity of L8G5-luciferase. Overexpressing ZNF307 in different cell lines also inhibits the transcriptional activities of p53 and p21. Moreover, ZNF307 works by reducing the p53 protein level and p53 protein reduction is achieved by increasing transcription of MDM2 and EP300. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation.

KW - KRAB

KW - ZNF307

KW - p21

KW - p53

UR - https://www.scopus.com/pages/publications/35148835287

U2 - 10.1016/j.bbrc.2007.08.180

DO - 10.1016/j.bbrc.2007.08.180

M3 - 文章

C2 - 17910948

AN - SCOPUS:35148835287

SN - 0006-291X

VL - 363

SP - 895

EP - 900

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway

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Keywords

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