X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

Wenpei Fan; Wenbo Bu; Zhen Zhang; Bo Shen; Hui Zhang; Qianjun He; Dalong Ni; Zhaowen Cui; Kuaile Zhao; Jiwen Bu; Jiulin Du; Jianan Liu; Jianlin Shi

doi:10.1002/anie.201504536

X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

Wenpei Fan, Wenbo Bu^*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

270 Scopus citations

Abstract

Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

Original language	English
Pages (from-to)	14026-14030
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	47
DOIs	https://doi.org/10.1002/anie.201504536
State	Published - 16 Nov 2015
Externally published	Yes

Keywords

NO release
X-ray radiation
hypoxic radiosensitization
luminescent imaging
on-demand therapy

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10.1002/anie.201504536

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title = "X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization",

abstract = "Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.",

keywords = "NO release, X-ray radiation, hypoxic radiosensitization, luminescent imaging, on-demand therapy",

author = "Wenpei Fan and Wenbo Bu and Zhen Zhang and Bo Shen and Hui Zhang and Qianjun He and Dalong Ni and Zhaowen Cui and Kuaile Zhao and Jiwen Bu and Jiulin Du and Jianan Liu and Jianlin Shi",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

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doi = "10.1002/anie.201504536",

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T1 - X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

AU - Fan, Wenpei

AU - Bu, Wenbo

AU - Zhang, Zhen

AU - Shen, Bo

AU - Zhang, Hui

AU - He, Qianjun

AU - Ni, Dalong

AU - Cui, Zhaowen

AU - Zhao, Kuaile

AU - Bu, Jiwen

AU - Du, Jiulin

AU - Liu, Jianan

AU - Shi, Jianlin

PY - 2015/11/16

Y1 - 2015/11/16

N2 - Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

AB - Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

KW - NO release

KW - X-ray radiation

KW - hypoxic radiosensitization

KW - luminescent imaging

KW - on-demand therapy

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U2 - 10.1002/anie.201504536

DO - 10.1002/anie.201504536

M3 - 文章

C2 - 26228648

AN - SCOPUS:84955207226

SN - 1433-7851

VL - 54

SP - 14026

EP - 14030

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 47

ER -

X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

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Keywords

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