Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions

Tiantian Chen; Haijian Yang; Yang Yang; Guangbin Dong; Dong Xing

doi:10.1021/acscatal.0c00019

Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions

Tiantian Chen
, Haijian Yang
, Yang Yang
, Guangbin Dong^*
, Dong Xing

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.

Original language	English
Pages (from-to)	4238-4243
Number of pages	6
Journal	ACS Catalysis
Volume	10
Issue number	7
DOIs	https://doi.org/10.1021/acscatal.0c00019
State	Published - 3 Apr 2020

Keywords

1
3-butadiene
atom-economy
crotylation
ketone
nickel
pH-neutral

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10.1021/acscatal.0c00019

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title = "Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions",

abstract = "We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.",

keywords = "1, 3-butadiene, atom-economy, crotylation, ketone, nickel, pH-neutral",

author = "Tiantian Chen and Haijian Yang and Yang Yang and Guangbin Dong and Dong Xing",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

year = "2020",

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doi = "10.1021/acscatal.0c00019",

language = "英语",

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T1 - Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions

AU - Chen, Tiantian

AU - Yang, Haijian

AU - Yang, Yang

AU - Dong, Guangbin

AU - Xing, Dong

PY - 2020/4/3

Y1 - 2020/4/3

N2 - We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.

AB - We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.

KW - 1

KW - 3-butadiene

KW - atom-economy

KW - crotylation

KW - ketone

KW - nickel

KW - pH-neutral

UR - https://www.scopus.com/pages/publications/85084085802

U2 - 10.1021/acscatal.0c00019

DO - 10.1021/acscatal.0c00019

M3 - 文章

AN - SCOPUS:85084085802

SN - 2155-5435

VL - 10

SP - 4238

EP - 4243

JO - ACS Catalysis

JF - ACS Catalysis

IS - 7

ER -

Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions

Abstract

Keywords

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