Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF3 γ-keto esters that uses Ph3PO as catalyst for the chemoselective conjugate reduction

Long Chen; Tao Da Shi; Jian Zhou

doi:10.1002/asia.201201130

Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF₃ γ-keto esters that uses Ph₃PO as catalyst for the chemoselective conjugate reduction

Long Chen
, Tao Da Shi
, Jian Zhou^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Reduce your waist: A highly efficient synthesis of α-CF₃ γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph₃PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl₃ for the chemoselective conjugate reduction.

Original language	English
Pages (from-to)	556-559
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	8
Issue number	3
DOIs	https://doi.org/10.1002/asia.201201130
State	Published - Mar 2013

Keywords

Lewis bases
Wittig reaction
organocatalysis
reduction
waste as catalyst

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abstract = "Reduce your waist: A highly efficient synthesis of α-CF3 γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph3PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl3 for the chemoselective conjugate reduction.",

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author = "Long Chen and Shi, \{Tao Da\} and Jian Zhou",

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AU - Shi, Tao Da

AU - Zhou, Jian

PY - 2013/3

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AB - Reduce your waist: A highly efficient synthesis of α-CF3 γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph3PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl3 for the chemoselective conjugate reduction.

KW - Lewis bases

KW - Wittig reaction

KW - organocatalysis

KW - reduction

KW - waste as catalyst

UR - https://www.scopus.com/pages/publications/84874251994

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DO - 10.1002/asia.201201130

M3 - 文章

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SN - 1861-4728

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IS - 3

ER -

Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF₃ γ-keto esters that uses Ph₃PO as catalyst for the chemoselective conjugate reduction

Abstract

Keywords

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