Visual search in alzheimer's disease - FMERI study

  • Jing Hao*
  • , Kun Cheng Li
  • , Ke Li
  • , De Xuan Zhang
  • , Wei Wang
  • , Bin Yan
  • , Yan Hui Yang
  • , Yan Wang
  • , Qi Chen
  • , Bao Ci Shan
  • , Xiao Lin Zhou
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

The aim was to investigate the neural basis of visual attention deficits in Alzheimer's disease (AD) patients using functional MRI. Thirteen AD patients and 13 age-matched controls participated in the experiment of two visual search tasks, one was a pop-out task, the other was a conjunction task. The fMRI data were collected on a 1. 5T MRI system and analyzed by SPM99. Both groups revealed almost the same networks engaged in both tasks, including the superior parietal lobule (SPL), frontal and occipito-temporal cortical regions (OTC), primary visual cortex and some subcortical structures. AD patients have a particular impairment in the conjunction task. The most pronounced differences were more activity in the SPL in controls and more activity in the OTC in AD patients. These results imply that the mechanisms controlling spatial shifts of attention are impaired in AD patients.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
EditorsGuang-Zhong Yang, Tianzi Jiang
PublisherSpringer Verlag
Pages204-212
Number of pages9
ISBN (Print)3540228772, 9783540228776
DOIs
StatePublished - 2004
Externally publishedYes

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3150
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

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