Visible-Light-Induced sp3C–H Functionalization of Alkyl Amines toward Tetrahydroquinoline Spiro[5.6] Compounds

Peng He; Yakun Jiang; Zongkang Wang; Nana Fei; Yan Wang; Lingkai Kong; Yanzhong Li

doi:10.1021/acs.orglett.5c01130

Visible-Light-Induced sp³C–H Functionalization of Alkyl Amines toward Tetrahydroquinoline Spiro[5.6] Compounds

Peng He
, Yakun Jiang
, Zongkang Wang
, Nana Fei
, Yan Wang
, Lingkai Kong^*
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

An efficient and green methodology for the synthesis of tetrahydroquinoline spiro[5.6] compounds by visible-light-induced sp³C–H functionalization reactions of alkyl amines has been developed. The advantages of this protocol include inexpensive photocatalysts, high diastereoselectivity, transition-metal-free properties, and wide-scope substrates.

Original language	English
Pages (from-to)	9843-9848
Number of pages	6
Journal	Organic Letters
Volume	27
Issue number	36
DOIs	https://doi.org/10.1021/acs.orglett.5c01130
State	Published - 12 Sep 2025

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10.1021/acs.orglett.5c01130

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abstract = "An efficient and green methodology for the synthesis of tetrahydroquinoline spiro[5.6] compounds by visible-light-induced sp3C–H functionalization reactions of alkyl amines has been developed. The advantages of this protocol include inexpensive photocatalysts, high diastereoselectivity, transition-metal-free properties, and wide-scope substrates.",

author = "Peng He and Yakun Jiang and Zongkang Wang and Nana Fei and Yan Wang and Lingkai Kong and Yanzhong Li",

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AU - He, Peng

AU - Jiang, Yakun

AU - Wang, Zongkang

AU - Fei, Nana

AU - Wang, Yan

AU - Kong, Lingkai

AU - Li, Yanzhong

PY - 2025/9/12

Y1 - 2025/9/12

N2 - An efficient and green methodology for the synthesis of tetrahydroquinoline spiro[5.6] compounds by visible-light-induced sp3C–H functionalization reactions of alkyl amines has been developed. The advantages of this protocol include inexpensive photocatalysts, high diastereoselectivity, transition-metal-free properties, and wide-scope substrates.

AB - An efficient and green methodology for the synthesis of tetrahydroquinoline spiro[5.6] compounds by visible-light-induced sp3C–H functionalization reactions of alkyl amines has been developed. The advantages of this protocol include inexpensive photocatalysts, high diastereoselectivity, transition-metal-free properties, and wide-scope substrates.

UR - https://www.scopus.com/pages/publications/105015864734

U2 - 10.1021/acs.orglett.5c01130

DO - 10.1021/acs.orglett.5c01130

M3 - 文章

C2 - 40878087

AN - SCOPUS:105015864734

SN - 1523-7060

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SP - 9843

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JO - Organic Letters

JF - Organic Letters

IS - 36

ER -

Visible-Light-Induced sp³C–H Functionalization of Alkyl Amines toward Tetrahydroquinoline Spiro[5.6] Compounds

Abstract

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