Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: Diverse SNArH reactions, cytotoxicity and spectral behavior

Fengyu Liu; Yi Xiao; Xuhong Qian; Zhichao Zhang; Jingnan Cui; Dawei Cui; Rong Zhang

doi:10.1016/j.tet.2005.08.106

Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: Diverse S_NAr^H reactions, cytotoxicity and spectral behavior

Fengyu Liu
, Yi Xiao
, Xuhong Qian^*
, Zhichao Zhang
, Jingnan Cui
, Dawei Cui
, Rong Zhang

^*Corresponding author for this work

Dalian University of Technology
East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The diverse reactivity of highly electron-deficient 8-oxo-8H-acenaphtho[1, 2-b]pyrrol-9-carbonitrile 1 is attractive for the preparation of derivatives bearing different substituents via S_NAr^H reaction with N, O, S nucleophiles. These derivatives were versatile, possessing potential antitumor activities and displaying tunable fluorescence spectral behavior.

Original language	English
Pages (from-to)	11264-11269
Number of pages	6
Journal	Tetrahedron
Volume	61
Issue number	47
DOIs	https://doi.org/10.1016/j.tet.2005.08.106
State	Published - 21 Nov 2005
Externally published	Yes

Keywords

Acenaphtho-heterocycles
Nucleophiles
SAr reaction

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10.1016/j.tet.2005.08.106

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title = "Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: Diverse SNArH reactions, cytotoxicity and spectral behavior",

abstract = "The diverse reactivity of highly electron-deficient 8-oxo-8H-acenaphtho[1, 2-b]pyrrol-9-carbonitrile 1 is attractive for the preparation of derivatives bearing different substituents via SNArH reaction with N, O, S nucleophiles. These derivatives were versatile, possessing potential antitumor activities and displaying tunable fluorescence spectral behavior.",

keywords = "Acenaphtho-heterocycles, Nucleophiles, SAr reaction",

author = "Fengyu Liu and Yi Xiao and Xuhong Qian and Zhichao Zhang and Jingnan Cui and Dawei Cui and Rong Zhang",

year = "2005",

month = nov,

day = "21",

doi = "10.1016/j.tet.2005.08.106",

language = "英语",

volume = "61",

pages = "11264--11269",

journal = "Tetrahedron",

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TY - JOUR

T1 - Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles

T2 - Diverse SNArH reactions, cytotoxicity and spectral behavior

AU - Liu, Fengyu

AU - Xiao, Yi

AU - Qian, Xuhong

AU - Zhang, Zhichao

AU - Cui, Jingnan

AU - Cui, Dawei

AU - Zhang, Rong

PY - 2005/11/21

Y1 - 2005/11/21

N2 - The diverse reactivity of highly electron-deficient 8-oxo-8H-acenaphtho[1, 2-b]pyrrol-9-carbonitrile 1 is attractive for the preparation of derivatives bearing different substituents via SNArH reaction with N, O, S nucleophiles. These derivatives were versatile, possessing potential antitumor activities and displaying tunable fluorescence spectral behavior.

AB - The diverse reactivity of highly electron-deficient 8-oxo-8H-acenaphtho[1, 2-b]pyrrol-9-carbonitrile 1 is attractive for the preparation of derivatives bearing different substituents via SNArH reaction with N, O, S nucleophiles. These derivatives were versatile, possessing potential antitumor activities and displaying tunable fluorescence spectral behavior.

KW - Acenaphtho-heterocycles

KW - Nucleophiles

KW - SAr reaction

UR - https://www.scopus.com/pages/publications/27144452964

U2 - 10.1016/j.tet.2005.08.106

DO - 10.1016/j.tet.2005.08.106

M3 - 文章

AN - SCOPUS:27144452964

SN - 0040-4020

VL - 61

SP - 11264

EP - 11269

JO - Tetrahedron

JF - Tetrahedron

IS - 47

ER -

Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: Diverse S_NAr^H reactions, cytotoxicity and spectral behavior

Abstract

Keywords

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