Uniform rattle-type hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property

Wenru Zhao; Hangrong Chen; Yongsheng Li; Ang Li; Meidong Lang; Jianlin Shi

doi:10.1002/adfm.200701317

Uniform rattle-type hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property

Wenru Zhao^*
, Hangrong Chen
, Yongsheng Li
, Ang Li
, Meidong Lang
, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

439 Scopus citations

Abstract

A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe₃O₄ particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H₂ reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g^-1 when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-release property, which follows a Fick's law.

Original language	English
Pages (from-to)	2780-2788
Number of pages	9
Journal	Advanced Functional Materials
Volume	18
Issue number	18
DOIs	https://doi.org/10.1002/adfm.200701317
State	Published - 23 Sep 2008
Externally published	Yes

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title = "Uniform rattle-type hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property",

abstract = "A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H2 reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g-1 when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-release property, which follows a Fick's law.",

author = "Wenru Zhao and Hangrong Chen and Yongsheng Li and Ang Li and Meidong Lang and Jianlin Shi",

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T1 - Uniform rattle-type hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property

AU - Zhao, Wenru

AU - Chen, Hangrong

AU - Li, Yongsheng

AU - Li, Ang

AU - Lang, Meidong

AU - Shi, Jianlin

PY - 2008/9/23

Y1 - 2008/9/23

N2 - A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H2 reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g-1 when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-release property, which follows a Fick's law.

AB - A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H2 reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g-1 when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-release property, which follows a Fick's law.

UR - https://www.scopus.com/pages/publications/53849119180

U2 - 10.1002/adfm.200701317

DO - 10.1002/adfm.200701317

M3 - 文章

AN - SCOPUS:53849119180

SN - 1616-301X

VL - 18

SP - 2780

EP - 2788

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 18

ER -

Uniform rattle-type hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property

Abstract

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