Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor

Yinyin Wei; Ying Li; Ningdan Zhang; Guoyue Shi; Litong Jin

doi:10.1016/j.ultsonch.2009.06.017

Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor

Yinyin Wei, Ying Li, Ningdan Zhang, Guoyue Shi, Litong Jin

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Hybrid nanocomposites of carboxyl-terminated generation 4 (G 4) poly(amidoamine) dendrimers (PAMAM) with gold nanoparticles (AuNPs) encapsulated inside them were synthesized under ultrasound irradiation. The obtained nanocomposites were used to fabricate highly sensitive amperometric glucose biosensor which exhibited a high and reproducible sensitivity of 2.9 mA/mM/cm², response time less than 5 s, linear dynamic range from 0.1 to 15.8 μM, correlation coefficient of R² = 0.9988, and limit of detection (LOD), based on S/N ratio (S/N = 3) of 0.05 μM. A value of 2.7 mM for the apparent Michaelis-Menten constant K_M^app was obtained. The high sensitivity, wider linear range, good reproducibility and stability make this biosensor a promising candidate for portable amperometric glucose biosensor.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Ultrasonics Sonochemistry
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.ultsonch.2009.06.017
State	Published - Jan 2010

Keywords

Glucose biosensor
Glucose oxidase
PAMAM-Au
Ultrasound irradiation

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10.1016/j.ultsonch.2009.06.017

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title = "Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor",

abstract = "Hybrid nanocomposites of carboxyl-terminated generation 4 (G 4) poly(amidoamine) dendrimers (PAMAM) with gold nanoparticles (AuNPs) encapsulated inside them were synthesized under ultrasound irradiation. The obtained nanocomposites were used to fabricate highly sensitive amperometric glucose biosensor which exhibited a high and reproducible sensitivity of 2.9 mA/mM/cm2, response time less than 5 s, linear dynamic range from 0.1 to 15.8 μM, correlation coefficient of R2 = 0.9988, and limit of detection (LOD), based on S/N ratio (S/N = 3) of 0.05 μM. A value of 2.7 mM for the apparent Michaelis-Menten constant KMapp was obtained. The high sensitivity, wider linear range, good reproducibility and stability make this biosensor a promising candidate for portable amperometric glucose biosensor.",

keywords = "Glucose biosensor, Glucose oxidase, PAMAM-Au, Ultrasound irradiation",

author = "Yinyin Wei and Ying Li and Ningdan Zhang and Guoyue Shi and Litong Jin",

year = "2010",

month = jan,

doi = "10.1016/j.ultsonch.2009.06.017",

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T1 - Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor

AU - Wei, Yinyin

AU - Li, Ying

AU - Zhang, Ningdan

AU - Shi, Guoyue

AU - Jin, Litong

PY - 2010/1

Y1 - 2010/1

N2 - Hybrid nanocomposites of carboxyl-terminated generation 4 (G 4) poly(amidoamine) dendrimers (PAMAM) with gold nanoparticles (AuNPs) encapsulated inside them were synthesized under ultrasound irradiation. The obtained nanocomposites were used to fabricate highly sensitive amperometric glucose biosensor which exhibited a high and reproducible sensitivity of 2.9 mA/mM/cm2, response time less than 5 s, linear dynamic range from 0.1 to 15.8 μM, correlation coefficient of R2 = 0.9988, and limit of detection (LOD), based on S/N ratio (S/N = 3) of 0.05 μM. A value of 2.7 mM for the apparent Michaelis-Menten constant KMapp was obtained. The high sensitivity, wider linear range, good reproducibility and stability make this biosensor a promising candidate for portable amperometric glucose biosensor.

AB - Hybrid nanocomposites of carboxyl-terminated generation 4 (G 4) poly(amidoamine) dendrimers (PAMAM) with gold nanoparticles (AuNPs) encapsulated inside them were synthesized under ultrasound irradiation. The obtained nanocomposites were used to fabricate highly sensitive amperometric glucose biosensor which exhibited a high and reproducible sensitivity of 2.9 mA/mM/cm2, response time less than 5 s, linear dynamic range from 0.1 to 15.8 μM, correlation coefficient of R2 = 0.9988, and limit of detection (LOD), based on S/N ratio (S/N = 3) of 0.05 μM. A value of 2.7 mM for the apparent Michaelis-Menten constant KMapp was obtained. The high sensitivity, wider linear range, good reproducibility and stability make this biosensor a promising candidate for portable amperometric glucose biosensor.

KW - Glucose biosensor

KW - Glucose oxidase

KW - PAMAM-Au

KW - Ultrasound irradiation

UR - https://www.scopus.com/pages/publications/69949180305

U2 - 10.1016/j.ultsonch.2009.06.017

DO - 10.1016/j.ultsonch.2009.06.017

M3 - 文章

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AN - SCOPUS:69949180305

SN - 1350-4177

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JO - Ultrasonics Sonochemistry

JF - Ultrasonics Sonochemistry

IS - 1

ER -

Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor

Abstract

Keywords

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