Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles

Chang Lei; Chun Xu; Amanda Nouwens; Chengzhong Yu

doi:10.1039/c6tb01023g

Ultrasensitive ELISA⁺ enhanced by dendritic mesoporous silica nanoparticles

Chang Lei, Chun Xu, Amanda Nouwens, Chengzhong Yu

University of Queensland

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

An ultrasensitive enzyme-linked immunosorbent assay (ELISA⁺) has been developed by using dendritic mesoporous silica nanoparticles (DMSNs) with high horseradish peroxidase (HRP) loading and easily accessible pore channels for signal amplification. A 2000 times enhancement of detection sensitivity compared to a commercial ELISA kit for insulin detection in serum is achieved.

Original language	English
Pages (from-to)	4975-4979
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	29
DOIs	https://doi.org/10.1039/c6tb01023g
State	Published - 2016
Externally published	Yes

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10.1039/c6tb01023g

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title = "Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles",

abstract = "An ultrasensitive enzyme-linked immunosorbent assay (ELISA+) has been developed by using dendritic mesoporous silica nanoparticles (DMSNs) with high horseradish peroxidase (HRP) loading and easily accessible pore channels for signal amplification. A 2000 times enhancement of detection sensitivity compared to a commercial ELISA kit for insulin detection in serum is achieved.",

author = "Chang Lei and Chun Xu and Amanda Nouwens and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6tb01023g",

language = "英语",

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T1 - Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles

AU - Lei, Chang

AU - Xu, Chun

AU - Nouwens, Amanda

AU - Yu, Chengzhong

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - An ultrasensitive enzyme-linked immunosorbent assay (ELISA+) has been developed by using dendritic mesoporous silica nanoparticles (DMSNs) with high horseradish peroxidase (HRP) loading and easily accessible pore channels for signal amplification. A 2000 times enhancement of detection sensitivity compared to a commercial ELISA kit for insulin detection in serum is achieved.

AB - An ultrasensitive enzyme-linked immunosorbent assay (ELISA+) has been developed by using dendritic mesoporous silica nanoparticles (DMSNs) with high horseradish peroxidase (HRP) loading and easily accessible pore channels for signal amplification. A 2000 times enhancement of detection sensitivity compared to a commercial ELISA kit for insulin detection in serum is achieved.

UR - https://www.scopus.com/pages/publications/84979501932

U2 - 10.1039/c6tb01023g

DO - 10.1039/c6tb01023g

M3 - 文章

AN - SCOPUS:84979501932

SN - 2050-750X

VL - 4

SP - 4975

EP - 4979

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 29

ER -

Ultrasensitive ELISA⁺ enhanced by dendritic mesoporous silica nanoparticles

Abstract

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