Ultrasensitive Detection of Ribonucleic Acid Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors

Ying Fu; Naixiang Wang; Anneng Yang; Zhiai Xu; Wen Zhang; Hong Liu; Helen Ka Wai Law; Feng Yan

doi:10.1021/acs.analchem.1c03441

Ultrasensitive Detection of Ribonucleic Acid Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors

Ying Fu
, Naixiang Wang
, Anneng Yang
, Zhiai Xu
, Wen Zhang
, Hong Liu
, Helen Ka Wai Law
, Feng Yan^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Hong Kong Polytechnic University
University of Strathclyde

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The analysis of ribonucleic acid (RNA) plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of RNA in physiological environments requires ultrahigh sensitivity of a detection technology. Here, we construct a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 h. Due to their inherent amplification function, the devices can detect miRNA cancer biomarkers from little-volume solutions with concentrations down to 10^-14M. The devices can distinguish blood miRNA expression levels at different cancer stages using a 4T1 mouse tumor model. The technique for ultrasensitive and fast detection of RNA biomarkers with high selectivity opens a window for mobile diagnosis of various diseases with low cost.

Original language	English
Pages (from-to)	14359-14364
Number of pages	6
Journal	Analytical Chemistry
Volume	93
Issue number	43
DOIs	https://doi.org/10.1021/acs.analchem.1c03441
State	Published - 2 Nov 2021

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title = "Ultrasensitive Detection of Ribonucleic Acid Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors",

abstract = "The analysis of ribonucleic acid (RNA) plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of RNA in physiological environments requires ultrahigh sensitivity of a detection technology. Here, we construct a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 h. Due to their inherent amplification function, the devices can detect miRNA cancer biomarkers from little-volume solutions with concentrations down to 10-14M. The devices can distinguish blood miRNA expression levels at different cancer stages using a 4T1 mouse tumor model. The technique for ultrasensitive and fast detection of RNA biomarkers with high selectivity opens a window for mobile diagnosis of various diseases with low cost.",

author = "Ying Fu and Naixiang Wang and Anneng Yang and Zhiai Xu and Wen Zhang and Hong Liu and Law, \{Helen Ka Wai\} and Feng Yan",

note = "Publisher Copyright: {\textcopyright} 2021 American Chemical Society",

year = "2021",

month = nov,

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doi = "10.1021/acs.analchem.1c03441",

language = "英语",

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T1 - Ultrasensitive Detection of Ribonucleic Acid Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors

AU - Fu, Ying

AU - Wang, Naixiang

AU - Yang, Anneng

AU - Xu, Zhiai

AU - Zhang, Wen

AU - Liu, Hong

AU - Law, Helen Ka Wai

AU - Yan, Feng

PY - 2021/11/2

Y1 - 2021/11/2

N2 - The analysis of ribonucleic acid (RNA) plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of RNA in physiological environments requires ultrahigh sensitivity of a detection technology. Here, we construct a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 h. Due to their inherent amplification function, the devices can detect miRNA cancer biomarkers from little-volume solutions with concentrations down to 10-14M. The devices can distinguish blood miRNA expression levels at different cancer stages using a 4T1 mouse tumor model. The technique for ultrasensitive and fast detection of RNA biomarkers with high selectivity opens a window for mobile diagnosis of various diseases with low cost.

AB - The analysis of ribonucleic acid (RNA) plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of RNA in physiological environments requires ultrahigh sensitivity of a detection technology. Here, we construct a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 h. Due to their inherent amplification function, the devices can detect miRNA cancer biomarkers from little-volume solutions with concentrations down to 10-14M. The devices can distinguish blood miRNA expression levels at different cancer stages using a 4T1 mouse tumor model. The technique for ultrasensitive and fast detection of RNA biomarkers with high selectivity opens a window for mobile diagnosis of various diseases with low cost.

UR - https://www.scopus.com/pages/publications/85118569942

U2 - 10.1021/acs.analchem.1c03441

DO - 10.1021/acs.analchem.1c03441

M3 - 文章

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SN - 0003-2700

VL - 93

SP - 14359

EP - 14364

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 43

ER -

Ultrasensitive Detection of Ribonucleic Acid Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors

Abstract

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