Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

Na Lu; Anran Gao; Pengfei Dai; Hongju Mao; Yuelin Wang; Tie Li

Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

Na Lu
, Anran Gao
, Pengfei Dai
, Hongju Mao
, Yuelin Wang
, Tie Li^*

^*Corresponding author for this work

CAS - Shanghai Institute of Microsystem and Information Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	2178-2180
Number of pages	3
ISBN (Electronic)	9780979806476
State	Published - 2014
Externally published	Yes
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CYFRA21-1
Label-free
Silicon nanowire field-effect-transistors (SiNW-FETs)
Ultrasensitive

Cite this

Lu, N., Gao, A., Dai, P., Mao, H., Wang, Y., & Li, T. (2014). Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2178-2180). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Lu, Na ; Gao, Anran ; Dai, Pengfei et al. / Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 2178-2180 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

@inproceedings{31133a53d99b43b4b9baf5b4850e6a9d,

title = "Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors",

abstract = "CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.",

keywords = "CYFRA21-1, Label-free, Silicon nanowire field-effect-transistors (SiNW-FETs), Ultrasensitive",

author = "Na Lu and Anran Gao and Pengfei Dai and Hongju Mao and Yuelin Wang and Tie Li",

note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

year = "2014",

language = "英语",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

pages = "2178--2180",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

}

Lu, N, Gao, A, Dai, P, Mao, H, Wang, Y & Li, T 2014, Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 2178-2180, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 26/10/14.

Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. / Lu, Na; Gao, Anran; Dai, Pengfei et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 2178-2180 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

AU - Lu, Na

AU - Gao, Anran

AU - Dai, Pengfei

AU - Mao, Hongju

AU - Wang, Yuelin

AU - Li, Tie

PY - 2014

Y1 - 2014

N2 - CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.

AB - CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.

KW - CYFRA21-1

KW - Label-free

KW - Silicon nanowire field-effect-transistors (SiNW-FETs)

KW - Ultrasensitive

UR - https://www.scopus.com/pages/publications/84941656392

M3 - 会议稿件

AN - SCOPUS:84941656392

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

SP - 2178

EP - 2180

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Lu N, Gao A, Dai P, Mao H, Wang Y, Li T. Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 2178-2180. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

Abstract

Publication series

Conference

UN SDGs

Keywords

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