TY - GEN
T1 - Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors
AU - Lu, Na
AU - Gao, Anran
AU - Dai, Pengfei
AU - Mao, Hongju
AU - Wang, Yuelin
AU - Li, Tie
N1 - Publisher Copyright:
© 14CBMS.
PY - 2014
Y1 - 2014
N2 - CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.
AB - CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.
KW - CYFRA21-1
KW - Label-free
KW - Silicon nanowire field-effect-transistors (SiNW-FETs)
KW - Ultrasensitive
UR - https://www.scopus.com/pages/publications/84941656392
M3 - 会议稿件
AN - SCOPUS:84941656392
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 2178
EP - 2180
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -
