Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

Sheng Min Sang; Min Liang Zou; Xiong Wen Zhang; Ai Na Lao; Zhong Liang Chen

doi:10.1080/10286020290019721

Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

Sheng Min Sang
, Min Liang Zou
, Xiong Wen Zhang
, Ai Na Lao^*
, Zhong Liang Chen

^*Corresponding author for this work

Chinese Academy of Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC₅₀ value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.

Original language	English
Pages (from-to)	67-70
Number of pages	4
Journal	Journal of Asian Natural Products Research
Volume	4
Issue number	1
DOIs	https://doi.org/10.1080/10286020290019721
State	Published - 2002
Externally published	Yes

Keywords

Allium tuberosum
HL-60
Spirostanol saponin
Tuberoside M

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10.1080/10286020290019721

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title = "Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum",

abstract = "Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.",

keywords = "Allium tuberosum, HL-60, Spirostanol saponin, Tuberoside M",

author = "Sang, \{Sheng Min\} and Zou, \{Min Liang\} and Zhang, \{Xiong Wen\} and Lao, \{Ai Na\} and Chen, \{Zhong Liang\}",

year = "2002",

doi = "10.1080/10286020290019721",

language = "英语",

volume = "4",

pages = "67--70",

journal = "Journal of Asian Natural Products Research",

issn = "1028-6020",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

AU - Sang, Sheng Min

AU - Zou, Min Liang

AU - Zhang, Xiong Wen

AU - Lao, Ai Na

AU - Chen, Zhong Liang

PY - 2002

Y1 - 2002

N2 - Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.

AB - Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.

KW - Allium tuberosum

KW - HL-60

KW - Spirostanol saponin

KW - Tuberoside M

UR - https://www.scopus.com/pages/publications/0036240456

U2 - 10.1080/10286020290019721

DO - 10.1080/10286020290019721

M3 - 文章

C2 - 11995668

AN - SCOPUS:0036240456

SN - 1028-6020

VL - 4

SP - 67

EP - 70

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 1

ER -

Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

Abstract

Keywords

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