Treatment of Alzheimer's disease with small-molecule photosensitizers

Yefei Jiang; Zhiyong Zeng; Jianhua Yao; Ying Guan; Peipei Jia; Xiaoli Zhao; Lin Xu

doi:10.1016/j.cclet.2022.107966

Treatment of Alzheimer's disease with small-molecule photosensitizers

Yefei Jiang, Zhiyong Zeng, Jianhua Yao, Ying Guan, Peipei Jia, Xiaoli Zhao, Lin Xu

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Alzheimer's disease is a neurodegenerative disease that signals for excess β-amyloid (Aβ) aggregation. Although people have made great attempts to control the aggregation of Aβ, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles.

Original language	English
Article number	107966
Journal	Chinese Chemical Letters
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.cclet.2022.107966
State	Published - May 2023

Keywords

Alzheimer's disease
Aβ aggregation
PDT
Photosensitizer

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10.1016/j.cclet.2022.107966

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title = "Treatment of Alzheimer's disease with small-molecule photosensitizers",

abstract = "Alzheimer's disease is a neurodegenerative disease that signals for excess β-amyloid (Aβ) aggregation. Although people have made great attempts to control the aggregation of Aβ, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles.",

keywords = "Alzheimer's disease, Aβ aggregation, PDT, Photosensitizer",

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AU - Jiang, Yefei

AU - Zeng, Zhiyong

AU - Yao, Jianhua

AU - Guan, Ying

AU - Jia, Peipei

AU - Zhao, Xiaoli

AU - Xu, Lin

PY - 2023/5

Y1 - 2023/5

N2 - Alzheimer's disease is a neurodegenerative disease that signals for excess β-amyloid (Aβ) aggregation. Although people have made great attempts to control the aggregation of Aβ, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles.

AB - Alzheimer's disease is a neurodegenerative disease that signals for excess β-amyloid (Aβ) aggregation. Although people have made great attempts to control the aggregation of Aβ, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles.

KW - Alzheimer's disease

KW - Aβ aggregation

KW - PDT

KW - Photosensitizer

UR - https://www.scopus.com/pages/publications/85149256332

U2 - 10.1016/j.cclet.2022.107966

DO - 10.1016/j.cclet.2022.107966

M3 - 文章

AN - SCOPUS:85149256332

SN - 1001-8417

VL - 34

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

M1 - 107966

ER -

Treatment of Alzheimer's disease with small-molecule photosensitizers

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Keywords

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