Transfer of sulfur: From simple to diverse

The introduction of sulfur atoms onto target molecules is an important area in organic synthesis, in particular in the synthesis of pharmaceutical compounds, and a wide variety of sulfuration agents have been developed for thionation reactions over the past few decades. In this Focus Review, we collect and summarize the C-S bond-formation reactions that have been used to construct C-S bonds in natural products and pharmaceutical compounds. C-S the day: Organosulfur compounds, including a wide range of natural products and drugs, have received considerable attention over the past few decades, owing to their remarkably bioactivity in biochemistry and medicinal chemistry. Numerous excellent sulfuration agents have been developed for the construction of C-S bonds. In this review, the various strategies for C-S bond formation are collected according to their sulfuration agents.