Abstract
A new practical and concise total synthesis of enantiopure camptothecin and SN-38 (14% overall yield, 99.9% ee and 99.9% purity) was described, starting from inexpensive and readily available materials. The development of column chromatography-free purification was achieved in all steps, which offers an economic industrial process to the camptothecin-family alkaloids.
| Original language | English |
|---|---|
| Pages (from-to) | 713-717 |
| Number of pages | 5 |
| Journal | Journal of Organic Chemistry |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| State | Published - 6 Jan 2012 |