Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

Lili Kong; Mingjin Rao; Jinjie Ou; Jun Yin; Weiqiang Lu; Mingyao Liu; Xiufeng Pang; Shuanhu Gao

doi:10.1039/c4ob01149j

Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

Lili Kong
, Mingjin Rao
, Jinjie Ou
, Jun Yin
, Weiqiang Lu
, Mingyao Liu
, Xiufeng Pang^*
, Shuanhu Gao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Total synthesis of cryptocin, a fungus metabolite, was achieved based on the biosynthetic hypothesis. A variety of derivatives of cryptocin, equisetin and fusarisetin A were prepared, wherein the racemization of C-3 and diastereoselectivity of C-5 were investigated. We further examined their inhibitory effects on breast cancer cell survival and metastasis, and summarized the structure-activity relationship.

Original language	English
Pages (from-to)	7591-7597
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	38
DOIs	https://doi.org/10.1039/c4ob01149j
State	Published - 14 Oct 2014

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title = "Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A",

abstract = "Total synthesis of cryptocin, a fungus metabolite, was achieved based on the biosynthetic hypothesis. A variety of derivatives of cryptocin, equisetin and fusarisetin A were prepared, wherein the racemization of C-3 and diastereoselectivity of C-5 were investigated. We further examined their inhibitory effects on breast cancer cell survival and metastasis, and summarized the structure-activity relationship.",

author = "Lili Kong and Mingjin Rao and Jinjie Ou and Jun Yin and Weiqiang Lu and Mingyao Liu and Xiufeng Pang and Shuanhu Gao",

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T1 - Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

AU - Kong, Lili

AU - Rao, Mingjin

AU - Ou, Jinjie

AU - Yin, Jun

AU - Lu, Weiqiang

AU - Liu, Mingyao

AU - Pang, Xiufeng

AU - Gao, Shuanhu

PY - 2014/10/14

Y1 - 2014/10/14

N2 - Total synthesis of cryptocin, a fungus metabolite, was achieved based on the biosynthetic hypothesis. A variety of derivatives of cryptocin, equisetin and fusarisetin A were prepared, wherein the racemization of C-3 and diastereoselectivity of C-5 were investigated. We further examined their inhibitory effects on breast cancer cell survival and metastasis, and summarized the structure-activity relationship.

AB - Total synthesis of cryptocin, a fungus metabolite, was achieved based on the biosynthetic hypothesis. A variety of derivatives of cryptocin, equisetin and fusarisetin A were prepared, wherein the racemization of C-3 and diastereoselectivity of C-5 were investigated. We further examined their inhibitory effects on breast cancer cell survival and metastasis, and summarized the structure-activity relationship.

UR - https://www.scopus.com/pages/publications/84907158069

U2 - 10.1039/c4ob01149j

DO - 10.1039/c4ob01149j

M3 - 文章

C2 - 25139438

AN - SCOPUS:84907158069

SN - 1477-0520

VL - 12

SP - 7591

EP - 7597

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 38

ER -

Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

Abstract

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