TiO2-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides

Jingjing Wan; Kun Qian; Liang Qiao; Yunhua Wang; Jilie Kong; Pengyuan Yang; Baohong Liu; Chengzhong Yu

doi:10.1002/chem.200802079

TiO₂-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides

Jingjing Wan^*
, Kun Qian
, Liang Qiao
, Yunhua Wang
, Jilie Kong
, Pengyuan Yang
, Baohong Liu
, Chengzhong Yu

^*Corresponding author for this work

Fudan University

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

A study was conducted to demonstrate a technique for selective enrichment of multiple phosphorylated peptides by manipulating the surface chemistry of TiO₂-modified macroporous ordered silica foams (Ti-MOSF-1). It was demonstrated that TiO₂-modified MOSF material had a surface area and that its surface was rich in coordinatively unsaturated Ti^IV, providing for more abundant and selective binding sites for phosphopeptides. The pure and modified MOSFs were also characterized in detail to understand their material characteristics and phosphopeptide enrichment behaviors. Some aggregates associated with the formation of Ti nanocrystals were also observed on the surface of Ti-MOSF-3 after the TiO₂ was modified three times. It was also demonstrated that the surface modification of MOSF and the incorporation of the TiO₂ were essential for the phosphopeptide enrichment behaviors.

Original language	English
Pages (from-to)	2504-2508
Number of pages	5
Journal	Chemistry - A European Journal
Volume	15
Issue number	11
DOIs	https://doi.org/10.1002/chem.200802079
State	Published - 2 Mar 2009
Externally published	Yes

Keywords

Enrichment
Macroporous
Peptides
Silica foams
Titanium

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10.1002/chem.200802079

Cite this

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title = "TiO2-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides",

abstract = "A study was conducted to demonstrate a technique for selective enrichment of multiple phosphorylated peptides by manipulating the surface chemistry of TiO2-modified macroporous ordered silica foams (Ti-MOSF-1). It was demonstrated that TiO2-modified MOSF material had a surface area and that its surface was rich in coordinatively unsaturated TiIV, providing for more abundant and selective binding sites for phosphopeptides. The pure and modified MOSFs were also characterized in detail to understand their material characteristics and phosphopeptide enrichment behaviors. Some aggregates associated with the formation of Ti nanocrystals were also observed on the surface of Ti-MOSF-3 after the TiO2 was modified three times. It was also demonstrated that the surface modification of MOSF and the incorporation of the TiO2 were essential for the phosphopeptide enrichment behaviors.",

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author = "Jingjing Wan and Kun Qian and Liang Qiao and Yunhua Wang and Jilie Kong and Pengyuan Yang and Baohong Liu and Chengzhong Yu",

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doi = "10.1002/chem.200802079",

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T1 - TiO2-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides

AU - Wan, Jingjing

AU - Qian, Kun

AU - Qiao, Liang

AU - Wang, Yunhua

AU - Kong, Jilie

AU - Yang, Pengyuan

AU - Liu, Baohong

AU - Yu, Chengzhong

PY - 2009/3/2

Y1 - 2009/3/2

N2 - A study was conducted to demonstrate a technique for selective enrichment of multiple phosphorylated peptides by manipulating the surface chemistry of TiO2-modified macroporous ordered silica foams (Ti-MOSF-1). It was demonstrated that TiO2-modified MOSF material had a surface area and that its surface was rich in coordinatively unsaturated TiIV, providing for more abundant and selective binding sites for phosphopeptides. The pure and modified MOSFs were also characterized in detail to understand their material characteristics and phosphopeptide enrichment behaviors. Some aggregates associated with the formation of Ti nanocrystals were also observed on the surface of Ti-MOSF-3 after the TiO2 was modified three times. It was also demonstrated that the surface modification of MOSF and the incorporation of the TiO2 were essential for the phosphopeptide enrichment behaviors.

AB - A study was conducted to demonstrate a technique for selective enrichment of multiple phosphorylated peptides by manipulating the surface chemistry of TiO2-modified macroporous ordered silica foams (Ti-MOSF-1). It was demonstrated that TiO2-modified MOSF material had a surface area and that its surface was rich in coordinatively unsaturated TiIV, providing for more abundant and selective binding sites for phosphopeptides. The pure and modified MOSFs were also characterized in detail to understand their material characteristics and phosphopeptide enrichment behaviors. Some aggregates associated with the formation of Ti nanocrystals were also observed on the surface of Ti-MOSF-3 after the TiO2 was modified three times. It was also demonstrated that the surface modification of MOSF and the incorporation of the TiO2 were essential for the phosphopeptide enrichment behaviors.

KW - Enrichment

KW - Macroporous

KW - Peptides

KW - Silica foams

KW - Titanium

UR - https://www.scopus.com/pages/publications/62349126304

U2 - 10.1002/chem.200802079

DO - 10.1002/chem.200802079

M3 - 文章

AN - SCOPUS:62349126304

SN - 0947-6539

VL - 15

SP - 2504

EP - 2508

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 11

ER -

TiO₂-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides

Abstract

Keywords

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