Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Wei Tan; Niklas Jänsch; Tina Öhlmann; Franz Josef Meyer-Almes; Xuefeng Jiang

doi:10.1021/acs.orglett.9b02784

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Wei Tan
, Niklas Jänsch
, Tina Öhlmann
, Franz Josef Meyer-Almes^*
, Xuefeng Jiang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.

Original language	English
Pages (from-to)	7484-7488
Number of pages	5
Journal	Organic Letters
Volume	21
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.9b02784
State	Published - 20 Sep 2019

Access to Document

10.1021/acs.orglett.9b02784

Cite this

@article{c2f852af9bde4cc3a8f194d64a9056f8,

title = "Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction",

abstract = "An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.",

author = "Wei Tan and Niklas J{\"a}nsch and Tina {\"O}hlmann and Meyer-Almes, \{Franz Josef\} and Xuefeng Jiang",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = sep,

day = "20",

doi = "10.1021/acs.orglett.9b02784",

language = "英语",

volume = "21",

pages = "7484--7488",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

AU - Tan, Wei

AU - Jänsch, Niklas

AU - Öhlmann, Tina

AU - Meyer-Almes, Franz Josef

AU - Jiang, Xuefeng

PY - 2019/9/20

Y1 - 2019/9/20

N2 - An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.

AB - An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.

UR - https://www.scopus.com/pages/publications/85072546231

U2 - 10.1021/acs.orglett.9b02784

DO - 10.1021/acs.orglett.9b02784

M3 - 文章

C2 - 31497974

AN - SCOPUS:85072546231

SN - 1523-7060

VL - 21

SP - 7484

EP - 7488

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Abstract

Access to Document

Other files and links

Fingerprint

Cite this