Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

Yonggang Li; Yufang Xu; Xuhong Qian; Baoyuan Qu

doi:10.1016/S0960-894X(03)00737-6

Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

Yonggang Li, Yufang Xu, Xuhong Qian, Baoyuan Qu

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 μM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.

Original language	English
Pages (from-to)	3513-3515
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(03)00737-6
State	Published - 20 Oct 2003
Externally published	Yes

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10.1016/S0960-894X(03)00737-6

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title = "Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms",

abstract = "A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 μM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.",

author = "Yonggang Li and Yufang Xu and Xuhong Qian and Baoyuan Qu",

year = "2003",

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TY - JOUR

T1 - Thiadiazole

T2 - A new family of intercalative photonuclease with electron transfer and radical mechanisms

AU - Li, Yonggang

AU - Xu, Yufang

AU - Qian, Xuhong

AU - Qu, Baoyuan

PY - 2003/10/20

Y1 - 2003/10/20

N2 - A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 μM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.

AB - A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 μM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.

UR - https://www.scopus.com/pages/publications/0141739812

U2 - 10.1016/S0960-894X(03)00737-6

DO - 10.1016/S0960-894X(03)00737-6

M3 - 文章

C2 - 14505660

AN - SCOPUS:0141739812

SN - 0960-894X

VL - 13

SP - 3513

EP - 3515

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 20

ER -

Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

Abstract

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