Abstract
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age‐related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual’s physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 1669-1685 |
| Number of pages | 17 |
| Journal | Nature Aging |
| Volume | 5 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2025 |
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In: Nature Aging, Vol. 5, No. 9, 09.2025, p. 1669-1685.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - The X-Age Project to construct a Chinese aging clock
AU - Li, Jiaming
AU - Jiang, Mengmeng
AU - Wang, Qiaoran
AU - Zheng, Zikai
AU - Shen, Jianghua
AU - Li, Jingyi
AU - Xiong, Muzhao
AU - Zheng, Yandong
AU - Lu, Xiaoyong
AU - Cai, Yusheng
AU - Fan, Yanling
AU - Geng, Lingling
AU - Ji, Qianzhao
AU - Peng, Qianqian
AU - Sun, Shuhui
AU - Wang, Yuanyuan
AU - Xin, Zijuan
AU - Yan, Kaowen
AU - Yang, Yuanhan
AU - Yu, Jun
AU - Yan, Haoteng
AU - Ai, Ding
AU - Bai, Yongping
AU - Bi, Yan
AU - Bian, Xiu Wu
AU - Bu, Pengcheng
AU - Cai, Jian Ping
AU - Cao, Chun Mei
AU - Cao, Feng
AU - Cao, Zhongwei
AU - Chai, Renjie
AU - Chan, Piu
AU - Chen, Chang
AU - Chen, Cheng Shui
AU - Chen, Chunying
AU - Chen, Di
AU - Chen, Hou Zao
AU - Chen, Lin
AU - Chen, Quan
AU - Chen, Xiao
AU - Chen, Xiaochun
AU - Chen, Yu
AU - Chen, Zi Jiang
AU - Ci, Weimin
AU - Dai, Zhe
AU - Ding, Qiurong
AU - Dong, Birong
AU - Dong, Jiahong
AU - Fan, Jian Gao
AU - Feng, Shiqing
AU - Feng, Xin
AU - Feng, Yun
AU - Fu, Xiaobing
AU - Fu, Xiaolong
AU - Gao, Feng
AU - Gao, Jiangang
AU - Gao, Qiang
AU - Gao, Shaorong
AU - Gu, Yonghao
AU - Guan, Youfei
AU - Guo, Feifan
AU - Han, Jing Dong J.
AU - Hao, Haiping
AU - Hao, Jihui
AU - He, Fuchu
AU - He, Jinhan
AU - He, Ming
AU - He, Mingguang
AU - He, Qiyang
AU - He, Zhiying
AU - He, Zuhong
AU - Hong, Huashan
AU - Hong, Jiaxu
AU - Hou, Shengping
AU - Hu, Cheng
AU - Hu, Ping
AU - Hu, Zhibin
AU - Huang, Canhua
AU - Huang, Jun
AU - Huang, Kai
AU - Huang, Pengyu
AU - Ji, Xunming
AU - Ji, Yong
AU - Jia, Shunji
AU - Jiang, Hong
AU - Jiang, Wenjian
AU - Jin, Lingjing
AU - Jin, Zi Bing
AU - Ju, Shenghong
AU - Ju, Zhenyu
AU - Kong, Qing Peng
AU - Kong, Wei
AU - Kong, Wei Jia
AU - Kong, Xiangqing
AU - Lei, Guanghua
AU - Li, Geng Lin
AU - Li, Ji
AU - Li, Jian
AU - Li, Mengfeng
AU - Li, Rong
AU - Li, Wei
AU - Li, Wei
AU - Li, Xiao Jun
AU - Li, Xin
AU - Liang, Qingfeng
AU - Liang, Zhen
AU - Lin, Haotian
AU - Liu, Baohua
AU - Liu, Cai Yue
AU - Liu, Changsheng
AU - Liu, Feng
AU - Liu, Jianfeng
AU - Liu, Jun Ping
AU - Liu, Ke
AU - Liu, Lin
AU - Liu, Pingsheng
AU - Liu, Qiang
AU - Liu, Qiang
AU - Liu, Tiemin
AU - Liu, Wenwen
AU - Liu, Xingguo
AU - Liu, Yajun
AU - Liu, Yong
AU - Liu, Youhua
AU - Liu, Youshuo
AU - Liu, Zhili
AU - Long, Xiao
AU - Lu, Yao
AU - Luo, Jian
AU - Luo, Xianghang
AU - Ma, Chunhong
AU - Ma, Shuai
AU - Ma, Xinran
AU - Mao, Jianhua
AU - Mao, Zhiyong
AU - Ng, Shyh Chang
AU - Nie, Guangjun
AU - Niu, Yuyu
AU - Peng, Yaojin
AU - Pu, Jun
AU - Qi, Jieyu
AU - Qiang, Li
AU - Qiao, Jie
AU - Qin, Yingying
AU - Qu, Aijuan
AU - Qu, Jing
AU - Ren, Jie
AU - Ren, Ruibao
AU - Ruan, Xiong Z.
AU - Shi, Anbing
AU - Shi, Haibo
AU - Shi, Jie
AU - So, Kwok Fai
AU - Song, Moshi
AU - Song, Weihong
AU - Songyang, Zhou
AU - Su, Jiacan
AU - Sun, Aijun
AU - Sun, Liang
AU - Sun, Qiang
AU - Sun, Yi Eve
AU - Sun, Yu
AU - Tang, Peifu
AU - Tang, Qi Qun
AU - Tang, Yi
AU - Tao, Jun
AU - Tao, Ling
AU - Tian, Mei
AU - Tian, Xiao Li
AU - Tian, Ye
AU - Tong, Xiaolin
AU - Wang, Cong Yi
AU - Wang, Haibo
AU - Wang, Hongmei
AU - Wang, Huating
AU - Wang, Jianan
AU - Wang, Jianwei
AU - Wang, Jianwei
AU - Wang, Jiqiu
AU - Wang, Liheng
AU - Wang, Lin
AU - Wang, Miao
AU - Wang, Qiang
AU - Wang, Si
AU - Wang, Sijia
AU - Wang, Songlin
AU - Wang, Wengong
AU - Wang, Xiaoming
AU - Wang, Xiaoning
AU - Wang, Yan
AU - Wang, Yan Jiang
AU - Wang, Yuan
AU - Wang, Yunfang
AU - Wang, Zhenning
AU - Wei, Xiawei
AU - Weng, Jianping
AU - Wu, Haitao
AU - Wu, Jihong
AU - Xia, Xiaohuan
AU - Xia, Yang
AU - Xiang, Andy Peng
AU - Xiao, Guozhi
AU - Xiao, Junjie
AU - Xiao, Yichuan
AU - Xiao, Zhi Xiong Jim
AU - Xie, Zhengwei
AU - Xiong, Wei
AU - Xu, Aimin
AU - Xu, Hua
AU - Xu, Lingyan
AU - Xu, Ming
AU - Yan, Liying
AU - Yang, Jiayin
AU - Yang, Jichun
AU - Yang, Liu
AU - Yang, Yun Gui
AU - Yang, Ze
AU - Yang, Zhenglin
AU - Yao, Hongjie
AU - Ye, Jing
AU - Yi, Chengqi
AU - Yi, Fan
AU - Yu, Honghua
AU - Yu, Yang
AU - Yu, Zhengrong
AU - Yuan, Ti Fei
AU - Yue, Jirong
AU - Yue, Rui
AU - Zhang, Chen
AU - Zhang, Chunxiang
AU - Zhang, Cuntai
AU - Zhang, Feng
AU - Zhang, Hongbo
AU - Zhang, Hongjia
AU - Zhang, Huijie
AU - Zhang, Jie
AU - Zhang, Jingjing
AU - Zhang, Licheng
AU - Zhang, Lingqiang
AU - Zhang, Luoying
AU - Zhang, Qingjiong
AU - Zhang, Wei
AU - Zhang, Weiping J.
AU - Zhang, Xin
AU - Zhang, Xuan
AU - Zhang, Yong
AU - Zhang, Yun Wu
AU - Zhang, Zhanjun
AU - Zhang, Zhuohua
AU - Zhao, Bing
AU - Zhao, Guoguang
AU - Zhao, Jiajun
AU - Zhao, Meng
AU - Zhao, Tongbiao
AU - Zheng, Jialin C.
AU - Zheng, Junke
AU - Zheng, Zhuozhao
AU - Zhou, Huixia
AU - Zhou, Lili
AU - Zhou, Xiangtian
AU - Zhou, Yongsheng
AU - Zhou, Zhongjun
AU - Zhu, Lan
AU - Zhu, Yizhun
AU - Zhu, Zhiming
AU - Zhuang, Wenjuan
AU - Zou, Weiguo
AU - Zhang, Weiqi
AU - Pei, Gang
AU - Liu, Guang Hui
N1 - Publisher Copyright: © Springer Nature America, Inc. 2025.
PY - 2025/9
Y1 - 2025/9
N2 - The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age‐related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual’s physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions.
AB - The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age‐related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual’s physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions.
UR - https://www.scopus.com/pages/publications/105015569417
U2 - 10.1038/s43587-025-00935-w
DO - 10.1038/s43587-025-00935-w
M3 - 文章
AN - SCOPUS:105015569417
SN - 2662-8465
VL - 5
SP - 1669
EP - 1685
JO - Nature Aging
JF - Nature Aging
IS - 9
ER -