The synthesis and bioactivity in vitro of functionalized mesoporous bioactive glasses

  • Jin Sun*
  • , Yongsheng Li
  • , Liang Li
  • , Wenru Zhao
  • , Lei Li
  • , Jianhua Gao
  • , Meiling Ruan
  • , Jianlin Shi
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Amino and carboxylic groups functionalized mesoporous bioactive glasses (denoted as N-MBGs and C-MBGs, respectively) were successfully synthesized through a post-grafting process. The in vitro bioactivities testing results indicate that the morphology and growing rate of carbonated hydroxyapatite (CHA) were affected dramatically by the introduced functional groups. Spherical CHA were observed grown on N-MBGs after soaking in the simulated body fluid (SBF) solution for 8h, which is different form the rod-like CHA grown on MBGs. While for C-MBGs, the nucleation and growth rate of CHA was decreased at increased contents of carboxylic groups. These demonstrate that it is possible to tune the rate of bone tissue regeneration by modifying MBGs with different kinds of functional groups.

Original languageEnglish
Title of host publicationZeolites and related materials
Subtitle of host publicationTrends, targets and challenges
EditorsAntoine Gedeon, Pascale Massiani, Florence Babonneau
Pages313-316
Number of pages4
EditionSUPPL. PART A
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameStudies in Surface Science and Catalysis
NumberSUPPL. PART A
Volume174
ISSN (Print)0167-2991

Keywords

  • Functionalization
  • bioactivity
  • carbonated hydroxyapatite
  • mesoporous bioactive glasses
  • morphology

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