The rise of ADP-ribose–ubiquitin

Chatrin Chatrin; Kang Zhu; Ivan Ahel

doi:10.1038/s41594-025-01651-0

The rise of ADP-ribose–ubiquitin

Chatrin Chatrin
, Kang Zhu
, Ivan Ahel^*

^*Corresponding author for this work

Health Science Center

University of Oxford

Research output: Contribution to journal › Comment/debate

12 Scopus citations

Abstract

Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.

Original language	English
Pages (from-to)	1582-1585
Number of pages	4
Journal	Nature Structural and Molecular Biology
Volume	32
Issue number	9
DOIs	https://doi.org/10.1038/s41594-025-01651-0
State	Published - Sep 2025

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abstract = "Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose{\textendash}ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.",

author = "Chatrin Chatrin and Kang Zhu and Ivan Ahel",

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N2 - Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.

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The rise of ADP-ribose–ubiquitin

Abstract

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