The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling

Xiao Gao; Hui Chen; Jian Liu; Shihui Shen; Qingwei Wang; Tracy M. Clement; Brian J. Deskin; Caiyu Chen; Dengpan Zhao; Lu Wang; Linjie Guo; Xueqing Ma; Bianhong Zhang; Yunfei Xu; Xiaotao Li; Lei Li

doi:10.1016/j.stemcr.2019.07.010

The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling

Xiao Gao
, Hui Chen
, Jian Liu
, Shihui Shen
, Qingwei Wang
, Tracy M. Clement
, Brian J. Deskin
, Caiyu Chen
, Dengpan Zhao
, Lu Wang
, Linjie Guo
, Xueqing Ma
, Bianhong Zhang
, Yunfei Xu
, Xiaotao Li
, Lei Li^*

^*Corresponding author for this work

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this article, Lei Li and colleagues show that ablation of REGγ, a proteasome activator, resulted in male subfertility, partially because of a decreased number of PLZF⁺ spermatogonia and spermatocytes. Mechanistically, REGγ loss significantly increased the abundance of p53 protein, and transcriptionally represses PLZF expression. Allelic p53 haplodeficiency partially rescued the defects in spermatogenesis observed in REGγ-deficient mice.

Original language	English
Pages (from-to)	559-571
Number of pages	13
Journal	Stem Cell Reports
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2019.07.010
State	Published - 10 Sep 2019

Keywords

PLZF
REGγ
mouse reproduction
p53
spermatogonial stem cells

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10.1016/j.stemcr.2019.07.010

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@article{14885f6ae28e4a1284eb36f201b20486,

title = "The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling",

abstract = "In this article, Lei Li and colleagues show that ablation of REGγ, a proteasome activator, resulted in male subfertility, partially because of a decreased number of PLZF+ spermatogonia and spermatocytes. Mechanistically, REGγ loss significantly increased the abundance of p53 protein, and transcriptionally represses PLZF expression. Allelic p53 haplodeficiency partially rescued the defects in spermatogenesis observed in REGγ-deficient mice.",

keywords = "PLZF, REGγ, mouse reproduction, p53, spermatogonial stem cells",

author = "Xiao Gao and Hui Chen and Jian Liu and Shihui Shen and Qingwei Wang and Clement, \{Tracy M.\} and Deskin, \{Brian J.\} and Caiyu Chen and Dengpan Zhao and Lu Wang and Linjie Guo and Xueqing Ma and Bianhong Zhang and Yunfei Xu and Xiaotao Li and Lei Li",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = sep,

day = "10",

doi = "10.1016/j.stemcr.2019.07.010",

language = "英语",

volume = "13",

pages = "559--571",

journal = "Stem Cell Reports",

issn = "2213-6711",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling

AU - Gao, Xiao

AU - Chen, Hui

AU - Liu, Jian

AU - Shen, Shihui

AU - Wang, Qingwei

AU - Clement, Tracy M.

AU - Deskin, Brian J.

AU - Chen, Caiyu

AU - Zhao, Dengpan

AU - Wang, Lu

AU - Guo, Linjie

AU - Ma, Xueqing

AU - Zhang, Bianhong

AU - Xu, Yunfei

AU - Li, Xiaotao

AU - Li, Lei

PY - 2019/9/10

Y1 - 2019/9/10

N2 - In this article, Lei Li and colleagues show that ablation of REGγ, a proteasome activator, resulted in male subfertility, partially because of a decreased number of PLZF+ spermatogonia and spermatocytes. Mechanistically, REGγ loss significantly increased the abundance of p53 protein, and transcriptionally represses PLZF expression. Allelic p53 haplodeficiency partially rescued the defects in spermatogenesis observed in REGγ-deficient mice.

AB - In this article, Lei Li and colleagues show that ablation of REGγ, a proteasome activator, resulted in male subfertility, partially because of a decreased number of PLZF+ spermatogonia and spermatocytes. Mechanistically, REGγ loss significantly increased the abundance of p53 protein, and transcriptionally represses PLZF expression. Allelic p53 haplodeficiency partially rescued the defects in spermatogenesis observed in REGγ-deficient mice.

KW - PLZF

KW - REGγ

KW - mouse reproduction

KW - p53

KW - spermatogonial stem cells

UR - https://www.scopus.com/pages/publications/85071659011

U2 - 10.1016/j.stemcr.2019.07.010

DO - 10.1016/j.stemcr.2019.07.010

M3 - 文章

C2 - 31402338

AN - SCOPUS:85071659011

SN - 2213-6711

VL - 13

SP - 559

EP - 571

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -

The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling

Abstract

Keywords

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