TY - JOUR
T1 - The effect of nC60 on tissue distribution of ibuprofen in Cyprinus carpio
AU - Chen, Qiqing
AU - Yin, Daqiang
AU - Hu, Xialin
AU - Wang, Rui
AU - Zhang, Chi
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/10/5
Y1 - 2014/10/5
N2 - The potential transfer of fullerene aqueous suspension (nC60) associated contaminants in vivo is one of the most significant and currently not well-understood environmental risks. In this study, the carrier function of nC60 for ibuprofen (IBU) was examined through whole-body and tissue distribution determination of nC60 and IBU in Cyprinus carpio. The results showed that the presence of nC60 only slightly increased the whole-body burden of IBU, because the amount of soluble IBU far exceeds that of nC60 associated form of IBU; while the presence of nC60 activated the catalase activity and enhanced the lipid peroxidation in the liver, suggesting an obviously induced oxidative damage to fish. With the presence of nC60, the uptake of IBU in both gill and digestive tract tissues increased obviously: the uptake of IBU in the gill was mainly from the desorption of nC60 associated IBU, and that in the digestive tract was both from nC60 associated IBU and soluble IBU. On the contrary, the nC60 reduced IBU uptake in the brain, probably due to the high accumulation of nC60 which blocked the blood brain barrier. Moreover, there was no significant increase in the muscle, which implies that the soluble form should be the main source of IBU accumulation in the muscle. The carrier function of nC60 observed in the present study indicates the potential transportation of other contaminants and the subsequently enhanced environmental risks. Capsule: Fullerene aqueous suspension functioned as a carrier to alter the tissue distribution of ibuprofen in Cyprinus carpio.
AB - The potential transfer of fullerene aqueous suspension (nC60) associated contaminants in vivo is one of the most significant and currently not well-understood environmental risks. In this study, the carrier function of nC60 for ibuprofen (IBU) was examined through whole-body and tissue distribution determination of nC60 and IBU in Cyprinus carpio. The results showed that the presence of nC60 only slightly increased the whole-body burden of IBU, because the amount of soluble IBU far exceeds that of nC60 associated form of IBU; while the presence of nC60 activated the catalase activity and enhanced the lipid peroxidation in the liver, suggesting an obviously induced oxidative damage to fish. With the presence of nC60, the uptake of IBU in both gill and digestive tract tissues increased obviously: the uptake of IBU in the gill was mainly from the desorption of nC60 associated IBU, and that in the digestive tract was both from nC60 associated IBU and soluble IBU. On the contrary, the nC60 reduced IBU uptake in the brain, probably due to the high accumulation of nC60 which blocked the blood brain barrier. Moreover, there was no significant increase in the muscle, which implies that the soluble form should be the main source of IBU accumulation in the muscle. The carrier function of nC60 observed in the present study indicates the potential transportation of other contaminants and the subsequently enhanced environmental risks. Capsule: Fullerene aqueous suspension functioned as a carrier to alter the tissue distribution of ibuprofen in Cyprinus carpio.
KW - Fullerene aqueous suspension
KW - Ibuprofen
KW - Oxidative damage
KW - Tissue distribution
UR - https://www.scopus.com/pages/publications/84905590632
U2 - 10.1016/j.scitotenv.2014.07.074
DO - 10.1016/j.scitotenv.2014.07.074
M3 - 文章
C2 - 25108247
AN - SCOPUS:84905590632
SN - 0048-9697
VL - 496
SP - 453
EP - 460
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -